RxPG - the perfect Rx for medical Post Graduate entrance blues!
Mobile Edition | Help/Newbie? | 24/7 Support
HOT | PrePG | MCQ | DNB | Careers | Books | Colleges | Dental | DocIndia | PLAB |  USMLE  | Australia | Canada | GLOBAL | OffBeat!
Articles | Forums | MCQ Crammer | Downloads | Mnemonics | Revision Tools | Recent Shouts | All Features

Heyde's syndrome

Author: Wikipedia, Posted on Friday, September 17 @ 19:45:39 IST by RxPG  

 FRIEND Add to My Pages   PRINTER Printer Friendly   FRIEND Email Story  FRIEND Download Story  Cardiology alerts 


Heyde's syndrome is a syndrome of aortic valve stenosis associated with gastrointestinal bleeding from colonic angiodysplasia. It is named after Dr. Edward C. Heyde, who first described the association in 1958.

Signs and symptoms

Aortic valve stenosis is a cause of heart failure and several other cardiac problems. In most patients, however, it goes unsuspected. A number of patients develops a bleeding tendency resembling that of platelet-derived coagulation problems, e.g. nosebleeds, bruising. Some bleed from angiodysplasias (small vascular malformations) of the colon. This can be subtle, causing mild anemia, or serious, warranting blood transfusions and surgery to control bleeding.


Angiodysplasias are usually identified on colonoscopy. In some patients, the cause of bleeding cannot be identified on colonoscopy, and only angiography of the colonic vasculature can identify the location of the angiodysplasias.

Aortic valve stenosis is identified on echocardiography (ultrasound studies of the heart), where a decreased Orifice Area of the aortic valve implies stenosis.

Routine testing for Von Willebrand disease (see below) generally fails to identify the coagulation abnormality, as only the high-molecular weight-multimers (HMWM) of von Willebrand factor are decreased. Only dynamic platelet function analysis (PFA) might be of some use in this respect.


In the 45 years following its initial description, no plausible explanations could be found for the association between aortic valve stenosis and gastrointestinal bleeding. Indeed, the association itself was questioned by a number of researchers. A number of reports stressed, however, that replacement of the diseased aortic valve often led to resolution of the coagulopathy.

Warkentin et al (1992) proposed that the link between aortic stenosis and bleeding was due to a mild form of von Willebrand disease. Some later reports confirmed the suspicion, including a 2002 study by the same group that showed resolution of the coagulation abnormality after aortic valve replacement.

In 2003 a study by Vincentelli et al finally gave an explanation for the remarkable phenomenon. It showed how the subtle form of von Willebrand disease present in Heyde syndrome patients resolved rapidly after heart valve replacement of the stenosed aortic valve. The coagulation abnormality, the study poses, is possibly caused by the increased breakdown of the very large von Willebrand factor molecule by its natural catabolic enzyme (named ADAMTS13 (http://bioinfo.weizmann.ac.il/cards-bin/carddisp?ADAMTS13)) under conditions of high shear stress around the valve.


Symptomatic treatment can be given in the form of blood transfusions. Desmopressin (DDAVP) releases Factor VIII storage pools and is used in mild to moderate cases of von Willebrand disease. Other approaches, including estrogen therapy, are discussed in the angiodysplasia article.

Vincentelli et al argue that severe forms of Heyde's syndrome might be sufficient reason for aortic valve replacement, even if the stenosis is otherwise clinically unimportant and is not likely to cause complications.


The syndrome was originally described in 1958 by Dr Edward C. Heyde, an internist living and working in Vancouver, WA in a letter to the New England Journal of Medicine. He reported ten patients with the association.

The statistical association was proven before there was any clue why patients with aortic valve stenosis had a higher occurrence of colonic bleeding. Already in 1958, a letter in the New England Journal of Medicine (Goldman et al) reported an odds ratio of almost 3.0 between the two diseases.


Goldman MJ. Aortic stenosis and gastrointestinal bleeding. N Engl J Med 1958;259:941.

Heyde EC: Gastrointestinal bleeding in aortic stenosis. N Engl J Med 1958;259:196.

Vincentelli A, Susen S, Le Tourneau T, et al. Acquired von Willebrand syndrome in aortic stenosis. N Engl J Med

(http://content.nejm.org/cgi/content/abstract/349/4/343) 2003;349:343-9. PMID 12878741


Warkentin TE, Moore JC, Morgan DG. Aortic stenosis and bleeding gastrointestinal angiodysplasia: Is acquired von Willebrand's disease the link? Lancet 1992;340:35-7.

Warkentin TE, Moore JC, Morgan DG. Resolution of bleeding from gastrointestinal angiodysplasia and von Willebrand syndrome type 2A after aortic valve replacement. N Engl J Med 2002;347:858-9.

Warkentin TE, Moore JC, Anand SS, Lonn EM, Morgan DG. Gastrointestinal bleeding, angiodysplasia, cardiovascular disease, and acquired von Willebrand syndrome. Transfus Med Rev 2003;17:272-86.

Note: This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Heyde%27s_syndrome".

4 (Excellent) 3(Good) 2(Good) 1(Bad)   

Recommended Books for Cardiology
 Books to read for Cardiology by RxPG

Related Cardiology articles
 How I Mastered The Heart Sounds!
 Right-Sided ECG In Right Ventricular Infarction.
 Clopidogrel - The Super Aspirin
 Digoxin - Cardiac Glycoside from Foxglove Plant
 Abciximab - A Platelet Aggregation Inhibitor
 Yale University school of medicine heart book
 Heyde's syndrome

Related Cardiology Discussions

Other articles by Wikipedia
 What is a Personal Digital Assistant (PDA) - Overview
 Randomised Controlled Trials (RCT) - Introduction, Classification and Overview
 Overview of Types and Various Phases of Clinical Trials
 What is a Meta Analysis?
 What is a Systematic Review?
 What is a Clinical Audit?
 Oseltamivir (Tamiflu) - First Oral Influenza Neuraminidase Inhibitor
 Clopidogrel - The Super Aspirin
 Donepezil - centrally acting reversible acetyl cholinesterase inhibitor
 Topiramate - A Monosaccharide Anticonvulsant
 Digoxin - Cardiac Glycoside from Foxglove Plant
 Vigabatrin = VIsual side effects + GABA TRansaminase INhibitor
 Olanzapine - Thienobenzodiazepine Atypical Antipsychotic
 Risperidone - Most Commonly Used Atypical Antipsychotic
 Clozapine - The First Atypical Antipsychotic
 Quetiapine - D1 and D2 dopamine antagonist
 Ziprasidone - The Atypical Amongst Atypical Antipsychotics
 Alemtuzumab - Monoclonal Antibody Used in the Treatment of Leukemia and Lymphoma
 Abciximab - A Platelet Aggregation Inhibitor
 Bevacizumab (Avastin) - An Anti-Angiogenesis Anti Cancer Drug

 Cardiology FAQ
  Browse all FAQs

Write an Article on Cardiology
You can share your exam experiences, preparation strategies, books you have read or just any information about Cardiology on RxPG website and we will publish it under your name.

Article Rating
Average Score: 5
Votes: 4

Most Read Article
Right-Sided ECG In Right Ventricular Infarction.

Related Links


· Cardiology section
· Articles by Wikipedia
· Add to my pages
· Printer friendly version
· PDF version
· Email article
· Feedback on this article
· Medical tutorials
· Related forum posts
· Related articles
· Related downloads
· Submit article
· Cardiology alerts
· Cardiology books
· Cardiology past papers

Most read story about Cardiology:
Right-Sided ECG In Right Ventricular Infarction.

Server Status: 190 pages served in last minute. Page generation time: 0.118 seconds

Site Maps: [Books] [News] [Forums] [Reviews] [Mnemonics]

sitemap - top30 - centuries - testimonials

About Us :: Disclaimer :: Contact Us :: Reporting abuse :: Terms of Services :: Privacy Policy

Advertise with RxPG!
Made in India by RxPG Medical Solutions Private Limited

"RxPG" is a Registered Trademark

Chrome Web Store YouTube Twitter LinkedIn Wikipedia Facebook