Contraindications to Use of Antimalarials
* Allergy to 4-aminoquinoline derivatives
* Retinopathy or visual field deterioration
Contraindications to Use of Anti-Tumor Necrosis Factor (Anti-TNF) Agents
* Sepsis or clinically manifest infections and/or abscesses
* Past medical history of hypersensitivity to infliximab or other murine proteins
Contraindications to Use of Azathioprine
* Known neoplastic disease
Contraindications to Use of Cyclophosphamide
* Pregnancy
* Chronic or active infection
* Liver disease
* History of neoplasia
* Renal failure is a relative contraindication that requires adjustment of dosage.
Contraindications to Use of Cyclosporin A
* Coexisting cancer (except non-melanoma skin cancer)
* Uncontrolled hypertension
* Renal dysfunction
* Uncontrolled infections
* Primary and secondary immunodeficiency
Contraindications to Use of D-penicillamine
* Kidney disease
* Blood disorders (e.g., leukopenia, thrombocytopenia)
Contraindications to Use of Leflunomide
* Serious immunodeficiency
* Dysplasias
* Uncontrolled infection (due to the theoretical possibility of immunosuppression)
* Moderate or severe renal failure (there is no experience in this group of patients)
* Liver function disorder
* Significant bone marrow disorder
* Severe hypoproteinemia
Contraindications to Use of Methotrexate
Absolute contraindications
* Pregnancy
* Alcohol abuse
* Hepatitis B or C
* Cirrhosis of any origin
Relative contraindications
* Renal failure
* Chronic pulmonary disease
* Active infection not associated with Feltys syndrome
Contraindications for Use of Gold Salts
* Severe liver or kidney disease
* Blood and marrow disorders
Contraindications for Use of Sulphasalazine
* Allergy to salicylates or sulfonamides
References:
1. Clinical practice guideline for the management of rheumatoid arthritis.
2. GUIPCAR Group. Clinical practice guideline for the management of rheumatoid arthritis. Madrid: Spanish Society of Rheumatology; 2001. 170 p. [430 references]
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