RxPG - the perfect Rx for medical Post Graduate entrance blues!
Mobile Edition | Help/Newbie? | 24/7 Support
HOT | PrePG | MCQ | DNB | Careers | Books | Colleges | Dental | DocIndia | PLAB |  USMLE  | Australia | Canada | GLOBAL | OffBeat!
Articles | Forums | MCQ Crammer | Downloads | Mnemonics | Revision Tools | Recent Shouts | All Features


Donepezil - centrally acting reversible acetyl cholinesterase inhibitor

Author: wikipedia, Posted on Friday, November 04 @ 04:21:40 IST by RxPG  

 FRIEND Add to My Pages   PRINTER Printer Friendly   FRIEND Email Story  FRIEND Download Story  Psychiatry alerts 

Psychiatry

Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a half life of about 70 hours, it can be taken once a day. Initial dose is 5 mg per day, which can be increased to 10 mg per day after an adjustment period of at least 4 weeks.

The clinical utility of donepezil is controversial. Presently, there is no proof that use of donepezil or other similar agents alters the course or progression of Alzheimer's disease. However, controlled studies have shown modest benefits in cognition and behavior with this and similar agents. Therefore, many neurologists, psychiatrists, and primary care physicians use donepezil in patients with Alzheimer's disease. As of the 22 March 2005, the UK National Institute for Clinical Excellence (NICE) withdrew its recommendation for use of the drug for mild-to-moderate AD, on the basis that there is no significant improvement in functional outcome; of quality of life or of behavioral symptoms. However, these data conflict with those of other reports, as is often the case in medicine.

Donepezil is sometimes used in combination with Memantine, a new agent for Alzheimer's disease which is in the same chemical class. The response to both together is superior to either alone.

Donepezil has been tested in other disorders which cause dementia including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications.


Note: This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Donepezil".



4 (Excellent) 3(Good) 2(Good) 1(Bad)   


Recommended Books for Psychiatry
 Books to read for Psychiatry by RxPG

Related Psychiatry articles
 Syndromes in Psychiatry
 Psychiatric Defence mechanisms - An Overview
 ICD diagnostic criteria in sexual disorders
 Schizophrenia - Overview of this common psychiatric disorder
 Organic mental disorders
 Confusing Features of Hallucinations
 Neurotic and Stress-Related Disorders
 Mental Disorders - An Introduction
 Features of Obsessive Compulsive Neurosis
 Which is the schizophrenia with worst prognosis?
 Suicide - Commonest cause of death among Psychiatric Patients
 Psychiatry Clinical Examination Format with Examples
 Psychotherapy: An Overview
 Mood Disorders (Affective Disorder)
 Defense Mechanisms in Psychodynamic Theory
 Mental Retardation (SYN. Learning Disabilities, Intellectual Impairment)
 Donepezil - centrally acting reversible acetyl cholinesterase inhibitor
 Olanzapine - Thienobenzodiazepine Atypical Antipsychotic
 Risperidone - Most Commonly Used Atypical Antipsychotic
 Clozapine - The First Atypical Antipsychotic

Related Psychiatry Discussions

Other articles by wikipedia
 What is a Personal Digital Assistant (PDA) - Overview
 Randomised Controlled Trials (RCT) - Introduction, Classification and Overview
 Overview of Types and Various Phases of Clinical Trials
 What is a Meta Analysis?
 What is a Systematic Review?
 What is a Clinical Audit?
 Oseltamivir (Tamiflu) - First Oral Influenza Neuraminidase Inhibitor
 Clopidogrel - The Super Aspirin
 Donepezil - centrally acting reversible acetyl cholinesterase inhibitor
 Topiramate - A Monosaccharide Anticonvulsant
 Digoxin - Cardiac Glycoside from Foxglove Plant
 Vigabatrin = VIsual side effects + GABA TRansaminase INhibitor
 Olanzapine - Thienobenzodiazepine Atypical Antipsychotic
 Risperidone - Most Commonly Used Atypical Antipsychotic
 Clozapine - The First Atypical Antipsychotic
 Quetiapine - D1 and D2 dopamine antagonist
 Ziprasidone - The Atypical Amongst Atypical Antipsychotics
 Alemtuzumab - Monoclonal Antibody Used in the Treatment of Leukemia and Lymphoma
 Abciximab - A Platelet Aggregation Inhibitor
 Bevacizumab (Avastin) - An Anti-Angiogenesis Anti Cancer Drug

 Psychiatry FAQ
  Browse all FAQs


Write an Article on Psychiatry
You can share your exam experiences, preparation strategies, books you have read or just any information about Psychiatry on RxPG website and we will publish it under your name.

Article Rating
Average Score: 3
Votes: 1




Most Read Article
Psychiatry; Free Online Mock Test 26

Related Links
· RxPG Postal Course
· Psychiatry Books at Amazon.com
· RxPG AIIMS Books
· Discuss Past Papers
· mediMOCK Forum
· RxPG Forums
· MRCPsych Forum
· NIMHANS Forum






ARTICLE TOOLS

· Psychiatry section
· Articles by wikipedia
· Add to my pages
· Printer friendly version
· PDF version
· Email article
· Feedback on this article
· Medical tutorials
· Related forum posts
· Related articles
· Related downloads
· Submit article
· Psychiatry alerts
· Psychiatry books
· Psychiatry past papers


Most read story about Psychiatry:
Psychiatry; Free Online Mock Test 26



Server Status: 104 pages served in last minute. Page generation time: 0.036 seconds

Site Maps: [Books] [News] [Forums] [Reviews] [Mnemonics]

sitemap - top30 - centuries - testimonials


About Us :: Disclaimer :: Contact Us :: Reporting abuse :: Terms of Services :: Privacy Policy

Advertise with RxPG!
Made in India by RxPG Medical Solutions Private Limited

"RxPG" is a Registered Trademark

Chrome Web Store YouTube Twitter LinkedIn Wikipedia Facebook