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1) . The following disease is associated with angiokeratoma :

One answer only.

   a. Krabbe's disease

   b. gaucher's disease

   c. Fabry's disease

   d. Tay-Sach's disease

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2) . Given that the chromosomes of mammalian cells may be 20 times as large as those of Escherichia coli, how can replication of mammalian chromosomes be carried out in just a few minutes?

One answer only.

   a. Eukaryotic DNA polymerases are extraordinarily fast compared with prokaryotic polymerases

   b. The higher temperature of mammalian cells allows for an exponentially higher replication rate

   c. Hundreds of replication forks work simultaneously on each piece of chromosomal DNA

   d. A great many different RNA polymerases carry out replication simultaneously on chromosomal DNA

   e. The presence of histones speeds up the rate of chromosomal DNA replication

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3) . Patients with hereditary nonpolyposis colon cancer have genes with microsatellite instability, that is, many regions containing abnormal, small loops of unpaired DNA. This is a result of a mutation affecting:

One answer only.

   a. Mismatch repair

   b. Chain break repair

   c. Base excision repair

   d. Depurination repair

   e. Nucleotide excision repair

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4) . Radiation therapy is employed for many cancers, including irradiation of the central nervous system to destroy lymphoblasts in leukemia. Which of the following accounts for the destruction of rapidly growing cells?

One answer only.

   a. Cross-linking of DNA

   b. Demethylation of DNA

   c. Cleavage of DNA double strands

   d. Disruption of DNA-RNA transcription complexes

   e. Disruption of purine rings in DNA

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5) . Which of the following enzymes can be described as a DNA-dependent RNA polymerase?

One answer only.

   a. DNA ligase

   b. Primase

   c. DNA polymerase III

   d. DNA polymerase I

   e. Reverse transcriptase

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6) . Which of the following is not a feature of supra tentorial tumors?

One answer only.

   a. Long tract signs

   b. Focal deficits

   c. Papilledema

   d. Seizues

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7) . 'Blue berry muffin' skin nodules are seen in :

One answer only.

   a. Pheochromocytoma

   b. Neuroblastma

   c. CA Stomach

   d. Umblical Adenoma

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8) . Adult Poly Cystic kidney Disease is associated with all, except :

One answer only.

   a. Cysts in Spleen

   b. Diverticulosis

   c. cysts in Pancreas

   d. Cysts in Lungs

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9) . Glue-sniffer's heart refers to substance abuse leading to :

One answer only.

   a. HOCM

   b. Dilated Cardiomyopathy

   c. Obstructive Cardiomyopathy

   d. Restrictive Cardimyopathy

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10) . Erythema Nodosum is not associated with :

One answer only.

   a. TB

   b. Yersinia

   c. Sulphonamides

   d. Pregnancy

   e. None