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List of Monoclonal Antobodies

Author: aminhars, Posted on Thursday, December 27 @ 02:27:53 IST by RxPG  

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Microbiology

Abciximab ReoPro 1994 chimeric inhibition of glycoprotein IIb/IIIa Cardiovascular disease

Infliximab Remicade 1998 chimeric I inhibition of TNF-a Inflammatory diseases Adalimumab Humira 2002 human inhibition of TNF-a signalling Inflammatory diseases

Natalizumab Tysabri 2006 humanized T cell VLA4 receptor Inflammatory diseases . (esp autoimmune-related multiple sclerosis therapy)

Omalizumab Xolair 2004 humanized Ig E Inflammatory diseases . (mainly allergy-related asthma therapy)

Eculizumab Soliris 2007 humanized complement C5 Inflammatory diseases . (PNH)

Efalizumab Raptiva 2002 humanized CD11a Inflammatory diseases . (psoriasis)

Alemtuzumab Campath 2001 humanized CD52 CLL Gemtuzumab Mylotarg 2000 humanized CD33 AML . (with calicheamicin)

Ri - tuximab Rituxan, Mabthera 1997 chimeric CD20 NHL Ibritumomab tiuxetan Zevalin 2002murine CD20 NHL (with yttrium-90 or indium-111) Tostumomab Bexxar 2003 murine CD20 NHL

Daclizumab Zenapax 1997 humanized IL-2 receptor Transplant rejection Basiliximab Simulect 1998 chimeric IL-2 receptor Transplant rejection MuromonabOrthoclone OKT3 1986 murine CD3 Receptor Transplant rejection

Bevaciz umab Avastin 2004 humanized vascular endothelial growth factor Colorectal cancer Panitumumab Vectibix 2006human epidermal growth factor receptor Colorectal cancer Cetuximab Erbitux 2004 chimeric epidermal growth factor receptor Colorectal cancer

Ranibizumab Lucentis 2006 humanized vascular endothelial growth factor Macular degeneration

Palivizumab Synagis 1998 humanized epitope of F protein of RSV Viral infection (espRSV)

Trastuzumab Herceptin 1998 humanized ErbB2 Breast cancer
-mab suffix monoclonal antibody.

if immediately before mab----u--its humane derived
. ---mo--its murine
. ----i----its chimeric.



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