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Syllabus for MRCP Part 1 [....Continued]

Author: RxPG, Posted on Friday, February 07 @ 00:00:00 IST by RxPG  

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MRCP Part 1


  • Mechanisms of hormone action and importance of
  • Receptors and substances involved in control of intracellular metabolism
  • Clinically relevant anatomical aspects of the speciality

  • Thyroid
    - Mechanisms of thyroid disease
    - Clinical presentation and treatment
    ---Thyroid hormone biosynthesis and its control
    ---Important drugs interfering with thyroid function
    ---Indications for use of various types of thyroid function test
    ---Autoimmunity and the thyroid
    ---Clinical features of thyrotoxicosis and hypothyroidism
    ---Goitre and its management
    ---Thyroid neoplasia
  • Hypothalamus/Pituitary
    - Physiology and testing of the control mechanisms of the endocrine system
    ---The physiology and Pathophysiology of control of pituitary hormone secretion
    ---The mechanisms of maintaining plasma osmolality
    ---Tests of pituitary diseases such as acromegaly, prolactinoma and Cushing's syndrome
    ---Drugs used in the treatment of pituitary disease
    ---Pituitary replacement therapy
  • Adrenal
    - Clinically relevant mechanisms of steroid biosynthesis
    ---Build-up of precursor compounds when there is defective cortisol biosynthesis in adrenocortical hyperplasia
    ---Tests for adrenocortical function
    ---Endocrine causes of hypertension and their differential diagnosis
    ---Clinical features and management of adrenal hyper- and hypofunction
    ---Complications of steroid therapy
  • Ovary
    - Physiology of ovarian functions
    - Conditions presenting to a physician
    ---Hormonal changes across the menstrual cycle
    ---Physiological changes in pregnancy
    ---The differential diagnosis of hirsutism and virilism
    ---Causes of amenorrhoea and anovulation
    ---Endocrine causes of infertility
  • Testis
    - Relevant investigations of urological infertility
    - Endocrine aspects of testicular functions
  • Growth
    - Factors controlling growth hormone secretion
    - Normal growth patterns
    - General medical and endocrine causes of short stature
    - Control of excessive growth
    - Growth hormone therapy and its complications
  • Parathyroid/bone
    - Control of bone turnover and disorders which can result of its failure
    ---Control of calcium metabolism
    ---Laboratory tests of parathyroid function
    ---The causes of hypercalcaemia
    ---Mechanisms of oesteomalacia
    ---Hyperparathyroidism, both primary and secondary
    ---The differentiation of primary, secondary and pseudo-hypoparathyroidism
    ---The differentiation of primary, secondary and pseudo-hypoparathyroidism
    ---The prophylaxis and treatment of osteoporosis
    ---Calcitonin and its role in metabolism
  • Diabetes mellitus
    - Detailed knowledge is required.
    ---Control of carbohydrate metabolism
    ---Genetics of diabetes
    ---Aetiology of type I diabetes and type 2 diabetes
    ---Long-term complications of diabetes
    ---Management of diabetic emergencies
    ---Differential diagnosis and treatment of hypoglycaemia
  • Disorders of lipid metabolism
    - Importance of this group disorder
    ---Control of cholesterol metabolism
    ---Aetiology of different types of hyperlipidaemia including both cholesterol and triglyceride disorders
    ---Indications for lipid lowering agents and their complications
    ---Types of secondary hyperlipidaemia


  • Physiology
    - Discrete functions of Glomerular ultrafiltration and tubular function
    - Proximal and distal parts of the nephron, with particular reference to control of water and electrolyte balance
    - Renal tubular acidosis
    - Cystinuria
    - Fluid, electrolyte, and acid-balance disturbances
  • Molecular biology and genetics
    - Genetic defects of common disorders including:
    ---Polycystic kidney
    ---Alport's syndrome
    ---Hypophosphataemic rickets
    - Inflammatory injury of the kidney mediated by various cytokines factors
  • Glomerular and tubular disorders
    - Glomerular ultra structure based upon techniques of light microscopy, electron microscopy and immunofluorescence as applied to renal biopsy
    - Primary Glomerular disorders as in idiopathic glomerulonephritis, and nephropathies of systemic diseases
    ---Diabetes mellitus
    ---Hypertensive nephrosclerosis
    - Interstitial nephritis, in particular vase s with reversible aetiology such as drug, heavy metals and analgesics
    - Metabolic sequelae of acute nephrotic and nephritic syndromes
    - Investigation and assessment of Glomerular and tubular disorders, including ultrasonic studies and nuclear medicine
    - Disturbed renal and metabolic functions in nephritic syndrome from a variety of causes
  • Infections of the kidney
    - Management of urinary tract infections including their detention, predisposing factors, prevention, and treatment
    - Anatomical abnormalities leading to repeated urinary tract infection
    ---Reflux nephropathy
    ---Prostatic hypertrophy
    - Other infections that might affect the kidney by direct invasion or by immune-complex deposition
  • Calculus formation within the urinary tract
    - Metabolic disorders predisposing to stone formation, their investigation, prevention and treatment
    ---Idiopathic hypercalciuria
    ---Primary Hyperparathyroidism
    ---Hyperoxaluria · Acute and chronic renal failure
    - Management of acute and chronic renal failure and of disturbed physiology involved
    - Pathophysiological changes and non-dialytic treatment in different stages of progressive renal failure
    - Principle of nutritional requirements and diatery intervention for patients with chronic renal failure
    - Other therapeutic means to slow down the progression of renal failure
  • Hypertension and renal problems in pregnancy
    - Renal adaptation to pregnancy
    - Management and profylaxis of renal disease and hypertension in pregnancy
  • Drug and the kidney
    - Role of the kidney in the normal elimination of drugs
    - Mechanisms by which drugs cause nephrotoxic damage
    - Principle of dose adjustment according to residual renal function
  • Renal replacement therapy
    - Different dialysis modalities and their complications
    - Complications related to immunosuppressive therapy following renal transplantation


  • Basic science
    - Structure and function of the epidermis and dermis
  • Clinical dermatology
    - Recognition of cutaneous symptoms and signs of systemic diseases (diseases affecting internal organs and presenting skin signs or symptoms)
    ---Collagen vascular disease such as SLE, systemic sclerosis
    ---Metabolic and endocrine disorders
    ---Infectious diseases
    ---Respiratory and cardiovascular diseases
    ---Common inherited diseases such as neurofibromatosis
    - Main dermatological complications of therapeutic immunosuppression (ex: systemic corticosteroid therapy, cyclosporin…) or of diseases such as HIV which cause immunosuppression
    - Differential diagnosis and plan of investigation of patients whom, present with the following cutaneous signs or symptoms which may indicate internal diseases:
    ---Generalised erythema
    ---Loss of hair
    ---Increased hair growth
    ---Common patterns of nail dystrophy such as clubbing
    ---Erythema nodosum
    ---Erythema multiform
    - Clinical features of the following skin diseases:
    ---Superficial fungal infections (dermatophytosis, pityriasis versicolor)
    ---Common skin cancers such as melanoma
    ---Vitiligo and alopecia areata
    ---Pemphigus and pemphigold
    ---Cutaneous herpes virus infections (herpes simplex, varicella zoster)
    ---Cutaneous staphylococcal and streptococcal infections
    ---Leprosy · Investigation
    - Principles of dermatological investigation such as patch testing
  • Drugs and therapy
    - Drugs which cause life-threatening skin conditions such as
    ---Stevens-Johnson syndrome,
    ---Toxic epidermal necrolysis

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