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Pharmacology; Free Online Mock Test 133 (PGI Pattern)

Author: RxPG, Posted on Tuesday, October 28 @ 00:00:00 IST by RxPG  

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Pharmacology

Multiple Choice Test



1) With regard to the cyanide radicals produced during the metabolism of sodium nitroprusside:

Choose 4 of the following options.
   1. Cyanmethaemoglobin is generated during the course of cyanide elimination.
   2. Cyanide production occurs as a result of a non-enzymatic process.
   3. Cyanide conversion to thiocyanate requires the enzyme rhodanase.
   4. Cyanide conversion to thiocyanate requires a source of sulphur.
   5. Cyanide conversion to thiocyanate requires a source of nitrate.





2) During the administration of Sodium Nitroprusside (SNP), there will be a tendency for:

Choose 4 of the following options.
   1. Intra-cranial pressure to rise.
   2. Platelet aggregation to be inhibited.
   3. Hypoxic pulmonary vasoconstriction to be inhibited.
   4. Coronary 'steal' to occur.
   5. Infusion rates of SNP of more than 3 microgram / kg / minute cause platelet aggregation



3) Which of the following drugs increases gastrointestinal motility?

One answer only.
   A. Fentanyl.
   B. Atropine.
   C. Neostigmine.
   D. Rocuronium.
   E. Glycopyrrolate.



4) With regard to remifentanil:

Choose 3 of the following options.
   1. It has a histamine-releasing effect equivalent to an equianalgesic dose of morphine.
   2. It has an elimination half-life of approximately 10 minutes.
   3. Its effect is prolonged in patients with pseudocholinesterase deficiency.
   4. It has a comparable potency to fentanyl.
   5. has initial distribution half life of one minute



5) Which of the following are features of digoxin toxicity?

Choose 3 of the following options.
   1. Nausea.
   2. Gynaecomastia.
   3. Xanthopsia.
   4. Hypokalaemia.
   5. Vomiting



6) In the case of a drug which exhibits first-order kinetics:

Choose 3 of the following options.
   1. A constant proportion of it is metabolised in a given period of time.
   2. It undergoes the most metabolism when plasma concentration is greatest.
   3. It has a constant elimination half-life - irrespective of plasma concentration.
   4. There is a linear relationship between plasma concentration and time.
   5. Example is alcohol



7) Magnesium:

Choose 4 of the following options.
   1. Can be used to control hypertension during surgery for phaeochromocytoma.
   2. Is an N-methyl-D-aspartate antagonist.
   3. Potentiates neuromuscular blockade.
   4. Is a pulmonary vasoconstrictor.
   5. Has anti dysrhythmic properties



8) Which of the following agents inhibit adenosine diphosphate (ADP) induced platelet aggregation when administered at typical clinical concentrations?

Choose 3 of the following options.
   1. Halothane.
   2. Sevoflurane
   3. Nitric Oxide.
   4. Isoflurane.
   5. Clodiporgel



9) Overdosage of 'Ecstasy' (3,4-methylene dioxymethamphetamine) may be associated with:

Choose 4 of the following options.
   1. Hyperthermia.
   2. Coagulopathy.
   3. Rhabdomyolysis.
   4. Peripheral neuropathy.
   5. Dehydration



10) A basic drug with a pKa of 5.0:

Choose 2 of the following options.
   1. Can be expected to readily cross the blood-brain barrier.
   2. Will be subject to increased excretion if the urine is alkalinised.
   3. Will be 50% ionised at a pH of 5.0.
   4. Will be almost totally ionised at normal blood pH (7.4).
   5. Cannot cross blood brain barrier


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