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1) Phenytoin:

Choose 4 of the following options.

   1. Is a Vaughan-Williams Class 1B anti-dysrhythmic.

   2. Can precipitate Stevens-Johnson Syndrome.

   3. Can be used for the treatment of digoxin toxicity.

   4. Can precipitate lupus erythematosus.

   5. Is self inducer of its metabolism

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2) With regard to adverse reactions to the administration of protamine:

Choose 2 of the following options.

   1. They are more likely to occur in diabetics.

   2. Previous exposure to heparin increases the risk of a reaction

   3. Previous exposure to protamine increases the risk of a reaction

   4. Pulmonary vasodilation is usually a feature.

   5. Previous exposure to warfarin increases the risk of a reaction

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3) Remifentanil:

Choose 2 of the following options.

   1. Has a similar lipid solubility to alfentanil.

   2. Relies on pseudocholinesterase for its metabolism.

   3. Does not need dose modification in the presence of renal failure.

   4. Can be used for induction of anaesthesia when spontaneous respiration is planned.

   5. Does need dose modification in renal failure

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4) Phenothiazines:

Choose 3 of the following options.

   1. Lower the seizure threshold.

   2. Possess anticholinergic activity.

   3. Possess local anaesthetic activity.

   4. Characteristically have small distribution volumes.

   5. Increases the seizure threshold

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5) Rapid bolus intravenous adenosine could be expected to terminate the following arrhythmias:

Choose 2 of the following options.

   1. Atrial flutter with 2:1 atrioventricular block

   2. Atrioventricular nodal re-entry tachycardia (AVNRT).

   3. Paroxysmal atrial fibrillation

   4. Orthodromic atrioventricular re-entry tachycardia

   5. Atrial fibrillations

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6) Lithium therapy can result in:

One answer only.

   1. Inappropriate ADH secretion.

   2. Sinus node dysfunction.

   3. Hyperglycaemia.

   4. Hypothyroidism.

   5. Diabetes Insipidus

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7) Which statement(s) is/are true with regard to Dantrolene:

Choose 4 of the following options.

   1. It has muscle relaxant properties.

   2. It has a role in the treatment of neuroleptic malignant syndrome.

   3. It lowers intracellular calcium levels.

   4. Its solubility increases with increasing pH.

   5. It can cause hyperthermia

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8) The anticoagulant effect of warfarin may be enhanced by

Choose 2 of the following options.

   1. Carbamazepine

   2, Metronidazole

   3. Vitamin K

   4. Aspirin

   5. Vitamin C

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9) Metabolic acidosis characteristically occurs in poisoning with

Choose 3 of the following options.

   1. Aspirin

   2. Ethylene glycol

   3. Methanol

   4. Phenobarbitone

   5. Glue sniffing

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10) Chlorpromazine:

Choose 4 of the following options.

   1. Can precipitate cholestatic jaundice.

   2. Has alpha-blocking activity.

   3. Can produce a photosensitivity rash.

   4. Lowers seizure threshold.

   5. Does not activate EEG