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Tumours of the Central Nervous System

Author: RxPG, Posted on Monday, February 03 @ 00:00:00 IST by RxPG  

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Pathology

World Health Organization Classification for 
the Tumours of the Central Nervous System

Neuroepithelial Tumours of the CNS

  1. Astrocytic tumours 
    1. Astrocytoma (WHO grade II) 
      1. variants: protoplasmic, gemistocytic, fibrillary, mixed 
    2. Anaplastic (malignant) astrocytoma (WHO grade III) 
    3. Glioblastoma multiforme (WHO grade IV) 
      1. variants: giant cell glioblastoma, gliosarcoma 


    4. Pilocytic astrocytoma (WHO grade I)
    5. Subependymal giant cell astrocytoma (WHO grade I)
    6. Pleomorphic xanthoastrocytoma (WHO grade I)
  2. Oligodendroglial tumours 
    1. Oligodendroglioma (WHO grade II) 
    2. Anaplastic (malignant) oligodendroglioma (WHO grade III) 
  3. Ependymal cell tumours 
    1. Ependymoma (WHO grade II) 
      1. variants: cellular, papillary, epithelial, clear cell, mixed 
    2. Anaplastic ependymoma (WHO grade III) 
    3. Myxopapillary ependymoma 
    4. Subependymoma (WHO grade I) 
  4. Mixed gliomas 
    1. Mixed oligoastrocytoma (WHO grade II) 
    2. Anaplastic (malignant) oligoastrocytoma (WHO grade III) 
    3. Others (e.g. ependymo-astrocytomas) 
  5. Neuroepithelial tumours of uncertain origin 
    1. Polar spongioblastoma (WHO grade IV) 
    2. Astroblastoma (WHO grade IV) 
    3. Gliomatosis cerebri (WHO grade IV) 
  6. Tumours of the choroid plexus 
    1. Choroid plexus papilloma 
    2. Choroid plexus carcinoma (anaplastic choroid plexus papilloma) 
  7. Neuronal and mixed neuronal-glial tumours 
    1. Gangliocytoma 
    2. Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos) 
    3. Ganglioglioma 
    4. Anaplastic (malignant) ganglioglioma 
    5. Desmoplastic infantile ganglioglioma 
    6. Central neurocytoma 
    7. Dysembryoplastic neuroepithelial tumour 
    8. Olfactory neuroblastoma (esthesioneuroblastoma) 
      1. variant: olfactory neuroepithelioma 
  8. Pineal Parenchyma Tumours 
    1. Pineocytoma 
    2. Pineoblastoma 
    3. Mixed pineocytoma/pineoblastoma 
  9. Tumours with neuroblastic or glioblastic elements (embryonal tumours) 
    1. Medulloepithelioma 
    2. Primitive neuroectodermal tumours with multipotent differentiation 
      1. medulloblastoma 
        1. variants: medullomyoblastoma, melanocytic medulloblastoma, desmoplastic medulloblastoma 
      2. cerebral primitive neuroectodermal tumour 
    3. Neuroblastoma 
      1. variant: ganglioneuroblastoma 
    4. Retinoblastoma 
    5. Ependymoblastoma 

    Non-neuroepithelial Tumours of the CNS

  10. Tumours of the Sellar Region 
    1. Pituitary adenoma 
    2. Pituitary carcinoma 
    3. Craniopharyngioma 
  11. Hematopoietic tumours 
    1. Primary malignant lymphomas 
    2. Plasmacytoma 
    3. Granulocytic sarcoma 
    4. Others
  12. Germ Cell Tumours 
    1. Germinoma 
    2. Embryonal carcinoma 
    3. Yolk sac tumour (endodermal sinus tumour) 
    4. Choriocarcinoma 
    5. Teratoma 
    6. Mixed germ cell tumours 
  13. Tumours of the Meninges 
    1. Meningioma 
      1. variants: meningothelial, fibrous (fibroblastic), transitional (mixed), psammomatous, angiomatous, microcystic, secretory, clear cell, chordoid, lymphoplasmacyte-rich, and metaplastic subtypes 
    2. Atypical meningioma 
    3. Anaplastic (malignant) meningioma 
  14. Non-menigothelial tumours of the meninges 
    1. Benign Mesenchymal 
      1. Osteocartilaginous tumours 
      2. Lipoma 
      3. Fibrous histiocytoma 
      4. Others 
    2. Malignant Mesenchymal 
      1. Chondrosarcoma 
      2. Hemangiopericytoma 
      3. Rhabdomyosarcoma 
      4. Meningeal sarcomatosis 
      5. Others 
    3. Primary Melanocytic Lesions 
      1. Diffuse melanosis 
      2. Melanocytoma 
      3. Malignant melanoma 
        1. Variant meningeal melanomatosis 
    4. Hemopoietic Neoplasms 
      1. Malignant lymphoma 
      2. Plasmactoma 
      3. Granulocytic sarcoma 
    5. Tumours of Uncertain Histogenesis 
      1. Hemangioblastoma (capillary hemangioblastoma) 
  15. Tumours of Cranial and Spinal Nerves 
    1. Schwannoma (neurinoma, neurilemoma) 
      1. Cellular, plexiform, and melanotic subtypes 
    2. Neurofibroma 
      1. Circumscribed (solitary) neurofibroma 
      2. Plexiform neurofibroma 
    3. Malignant peripheral nerve sheath tumour (Malignant schwannoma) 
      1. Epithelioid 
      2. Divergent mesenchymal or epithelial differentiation 
      3. Melanotic 
  16. Local Extensions from Regional Tumours 
    1. Paraganglioma (chemodectoma) 
    2. Chordoma 
    3. Chodroma 
    4. Chondrosarcoma 
    5. Carcinoma 
  17. Metastatic tumours 
  18. Unclassified Tumours 
  19. Cysts and Tumour-like Lesions 
    1. Rathke cleft cyst 
    2. Epidermoid 
    3. Dermoid 
    4. Colloid cyst of the third ventricle 
    5. Enterogenous cyst 
    6. Neuroglial cyst 
    7. Granular cell tumour (choristoma, pituicytoma) 
    8. Hypothalamic neuronal hamartoma 
    9. Nasal glial herterotopia 
    10. Plasma cell granuloma 



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