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Online Mock Test 144 (PGI Pattern)

Author: RxPG, Posted on Friday, June 11 @ 00:00:00 IST by RxPG  

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Multiple Choice Test

mediMOCK 144

1) Regarding drug administration:

Choose 2 of the following options.
   a) the sublingual route avoids first-pass inactivation in the liver
   b) suppositories expose the drug to first-pass metabolism
   c) distribution of nebulised drug in the respiratory tree depends on the particle size
   d) highly water soluble drugs are administered by the transdermal route
   e) drugs given by the oral route should have a very high extraction ratio

2) Regarding protein binding of drugs in the plasma:

Choose 3 of the following options.
   a) highly protein bound drugs have a longer biological half-life
   b) protein binding is markedly different in arterial and venous blood
   c) free drug concentration is not altered in hypoalbuminaemic states
   d) alpha-1 acid glycoprotein principally binds to basic drugs
   e) the greater the protein binding, the lesser the volume of distribution

3) Alprostadil (PGE1) and Epoprostenol (PGI2):

Choose 4 of the following options.
   a) are principally metabolised in the lungs
   b) dilate ductus arteriosus to increase pulmonary blood flow in neonates
   c) inhibit platelet aggregation
   d) improve oxygenation in ARDS patients when used by the nebulised route
   e) do not cause apnoea in neonates

4) The following statements about drug half-life are correct:

Choose 3 of the following options.
   a) the half-life of a drug is shorter than its time constant
   b) drugs given by infusion without a bolus reach a steady state in five half-lives
   c) the extent of drug distribution into the total body water or extracellular fluid is unlikely to affect t1/2
   d) context-sensitive half–life can be used for any drug
   e) about 94% of a drug is cleared from the body in four half-lives

5) First-order processes:

Choose 4 of the following options.
   a) apply to enzyme-mediated reactions
   b) are characterised by high rates of reaction when the concentrations of reacting substances are high, and vice verse
   c) can properly be described in terms of t1/2
   d) are involved in the elimination of most drugs
   e) change to zero-order kinetic at very high drug doses

6) Regarding drug clearance by the body:

Choose 2 of the following options.
   a) this only refers to elimination by the kidney
   b) this refers to the volume of plasma cleared of the drug in unit time
   c) it cannot exceed the glomerular filtration rate
   d) it is dependent on its volume of distribution
   e) hepatic clearance is expressed as extraction ratio

7) 5-HT:

Choose 4 of the following options.
   a) is synthesised from tyrosine by enterochromaffin cells of the gastrointestinal tract
   b) is also an endogenous neurotransmitter in the brain
   c) is metabolised by monoamine oxidase to hydroxyindole acetic acid
   d) is degraded to a great extent by pulmonary endothelial cells
   e) can cause vasoconstriction and increased gastrointestinal motility

8) Concerning metabolism of following drugs:

Choose 4 of the following options.
   a) lidocaine is metabolised to monoethylglycinexylidide (MEGX) in the liver
   b) lithium is almost entirely excreted unchanged by the kidney
   c) gentamicin is metabolised in the liver and excreted in the bile
   d) chlorpromazine is degraded via microsomal oxidative metabolism in the liver
   e) levodopa crosses the blood-brain barrier and is then converted to dopamine

9) Regarding arterial blood gas analysis:

Choose 4 of the following options.
   a) hydrogen, oxygen and CO2 electrodes measure at 37 degrees C
   b) PaO2 read by gas analyser would be higher than patient’s PaO2 at 37 degrees C
   c) the pH of the blood rises by 0.015 units per 10 degrees C decrease in body temperature
   d) the alpha-stat approach is to keep uncorrected PaCO2 and pH at normal levels
   e) PaCO2 of a patient at 30 degrees C will be lower than that at body temperature

10) Regarding fibrinolysis:

Choose 4 of the following options.
   a) streptokinase converts plasminogen to plasmin
   b) tranexamic acid is a potent activator of plasmin
   c) aprotinin has antiplasmin activity
   d) urokinase is a plasminogen activator
   e) rT-PA converts plasminogen to plasmin

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