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Eponyms - T

Author: Andrew J. Yee, M.D., Posted on Tuesday, July 27 @ 00:00:00 IST by RxPG  

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Eponyms

TAKAYASU'S DISEASE
aortic arch syndrome, pulseless disease; panartertis of the great vessels that's most common in Asian women

TAMM HORSFALL PROTEIN
uromodulin, major component of renal casts; 30-50 mg secreted per day by cells in thick ascending limb; homologous to GP2, a protein secreted from the acinar cell and a major component of plugs in noncalcific chronic pancreatitis

TANGIER DISEASE
rare recessive disease characterized by enlarged orange tonsils, peripheral neuropathy affecting small fibers involved in in pain and temperature, and a near-complete absence of HDL-cholesterol; ABC1, the ATP binding-cassette transporter 1 gene, mutated in TD; gene mediates efflux of cholesterol from cells

TAY-SACHS DISEASE
autosomal recessive sphingolipidosis; GM2 gangliosidosis, results from mutations that affect chr15 and cause a severe deficiency in beta hexosaminidase A; blindness and cherry-red spot (c.f. Sandhoff's disease with similar symptoms where both beta hexosaminidase A and B)


TERRY'S NAILS
mostly whitish with a distal band of reddish brown; may be seen with aging and in people with chronic diseases such as cirrhosis of the liver, congestive heart failure, and non-insulin-dependent diabetes; seen in 10% of uremics

TERSON'S SYNDROME
intra-vitreous hemorrhage associated with subarachnoid hemorrhage

THOMPSON'S TEST
verifies if gastroc-soleus complex intact; squeeze calf belly, foot should plantar flex

THOMSEN'S DISEASE
myotonia congenita, autosomal dominant

THOMSEN-FRIEDENREICH ANTIGEN
cryptic antigen in membranes of erythrocytes, platelets, and glomerular capillary endothelial cells exposed by S. pneumoniae-derived neuraminidase removal of sialic acid

THOREL'S PATHWAY
posterior internodal tract in atrial conduction system

THUMB SIGN
in Marfan's disease, Ehlers-Danlos syndrome, and similar syndromes, thumb protrudes from clenched fist

TIETZE SYNDROME
discomfort localized in swelling of the costochondral and costosternal joints, which are painful on palpation; may be perceived as breast pain

TINEL'S SIGN
a sensation of tingling or pins and needles felt in distal extremity when percussion is made over the site of an injured nerve; it indicates a partial lesion or early regeneration of the nerve; 60% sens, 67% spec

TODD'S PARALYSIS
transient hemiparesis in postictal period, resolves over a period of 0.5-360 hours, suggests focal brain lesion as cause

TOLDT, WHITE LINES OF
the peritoneal reflections of the ascending and descending colon

TOLOSA-HUNT SYNDROME
idiopathic inflammation of the cavernous sinus producing painful palsy of third, fourth, or sixth cranial nerve

TOURETTE'S SYNDROME
chronic multiple motor and verbal tics, symptoms typically begin before 21 y.o., first signs motor tics in 80% and vocal tics in 20% but eventually both motor and vocal; higher than expected number of left-handedness and ambidexterity; 40-50% involve self-mutilation such as nail-biting, hair-pulling, etc.

TOWNE'S VIEW
AP view with the X ray tube angled caudad to show the occipital bone

TRAUBE'S SIGN
in aortic regurgitation "pistol shot sounds" referring to booming systolic and diastolic sounds over the femoral artery

TRAUBE'S SPACE
a crescentic space about 12 cm wide, bounded medially by the left border of the sternum, above by an oblique line from the 6th costal cartilage to the lower border of the 8th or 9th rib in the mid-axillary line and below by the costal margin; the percussion tone here is normally tympanitic, because of the underlying stomach, but is modified by pulmonary emphysema, a pleural effusion, or an enlarged spleen

TREACHER COLLINS SYNDROME
first arch syndrome, mandibulofacial dysplasia, caused by AD gene, resulting in malar hypoplasia with down-slanting palpebral fissures, defects in the lower eyelids, deformed external ears, and sometimes abnormalities of the middle and internal ears

TRENDELENBURG'S GAIT
waddling gait in people with weakness or paresis of gluteal muscles; seen in progressive muscular dystrophy

TRENDELENBURG'S SIGN
sign of weakness of gluteus medius muscle seen as when standing on one leg, failure to elevate contralateral side of pelvis; may be due to congenital dislocation of hip, trochanteric fracture, polio, spinal nerve root lesions with muscular atrophy

TRIETZ, LIGAMENT OF
the suspensory muscle of the duodenum which supports the duodenojejunal flexure

TROUSSEAU'S SIGN
in hypocalcemia and latent tetany, carpal spasm induced by occluding the brachial artery for 3 min with an inflated BP cuff

TROUSSEAU'S SYNDROME
migratory thrombophlebitis, may be encountered with deep-seated cancers, most often with carcinomas of the pancreas or lung

TULLIO'S PHENOMENON
induction of vertigo by loud noises, i.e. sound-induced vestibular activation

TURCOT'S SYNDROME
rare variant of familial adenomatous polyposis, with combination of adenomatous colonic polyposis and tumors of the CNS, mostly gliblastoma multiforme

TURNER'S SYNDROME
females with XO, short, low-set ears, shield chest, congenital heart defect (usually coarctation), café-au-lait spots, freckles, webbed neck, lymphedema

TZANCK SMEAR
cytologic technique most often used in the diagnosis of herpesvirus infections (simplex or varicella-zoster); multinucleated giant cells suggest the presence of herpes; named after Arnault Tzanck


Note: Eponyms Database Author: Andrew J. Yee, M.D. (website: eponyms.net)

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