CHANGES IN HARRISONS PRINCIPLES OF INTERNAL MEDICINE CATEGORISED.
SYNOPSIS OF MAIN CHANGES IN 16TH EDITION!
this edition focuses more directly and extensively than ever on crucial aspects of clinical practice. Areas of emphasis include the approach to the patient, differential diagnosis, state-of-the-art treatment options, and disease prevention.
Key topics, such as the immune system and HIV infection/AIDS, are covered in chapters amounting to "mini-textbooks."
New sections offer information on the formidable challenges posed by critical care medicine and by the threat of bioterrorism.
New chapters provide coverage of highly relevant clinical topics such as disease screening, perimenopausal management and hormone replacement therapy, and end-of-life care.
Virtually every chapter in this edition has been substantially rewritten, and 46 chapters either are entirely new or have new authors.
These is the changes in Harrisons principles of internal medicine based on the information provided in the preface of the new edition.
The changes, modifications and additions are listed under three headings
I. New sections.
II. New chapters
III. Revised, rewritten or changed
topics revised from pervious editions,rewritten by new authors.
IV. Categorical changes
Some topics have been grouped under specific headings for better understanding or few topics have been discussed in separate sections(eg. Infections by retroviruses.)because of the importance of such topics.
I.NEW SECTIONS
PART SEVEN BIOTERRORISM AND CLINICAL MEDICINE
Microbial Terrorism H. Clifford Lane/Anthony S. Fauci
Chemical Bioterrorism Charles G. Hurst/Jonathan Newmark/James A. Romano
Radiation Bioterrorism Zelig A. Tochner/Ofer Lehavi/Eli Glatstein
PART TEN CRITICAL CARE MEDICINE
SECTION 1: RESPIRATORY CRITICAL CARE
Principles of Critical Care Medicine John P. Kress/Jesse B. Hall
Respiratory Failure Craig Lilly/Edward P. Ingenito/Steven D. Shapiro
Acute Respiratory Distress Syndrome Bruce D. Levy/Steven D.
Shapiro
Mechanical Ventilatory Support Edward P. Ingenito/Jeffrey M. Drazen
Section 2: Shock and Cardiac Arrest
Approach to the Patient with Shock Ronald V. Maier
Severe Sepsis and Septic Shock Robert S. Munford
Cardiogenic Shock and Pulmonary Edema Judith S. Hochman/David Ingbar
Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death Robert J. Myerburg/Agustin Castellanos
Section 3: Neurologic Critical Care
Acute Confusional States and Coma Allan H. Ropper
Critical Care Neurology J. Claude Hemphill
this part deals with three main areas: respiratory critical care, shock and cardiac arrest, and neurologic critical care.
II. NEW CHAPTERS.
PART 1-"INTRODUCTION TO CLINICAL MEDICINE,"
Screening and Prevention of Disease Gary J. Martin
contains a new chapter discusses the principles and guidelines used in screening for common conditions such as cancer, hypertension, lipid disorders, and osteoporosis.
Medical Evaluation of the Surgical Patient Gerald W. Smetana
offers a pragmatic approach to the medical evaluation of patients who are about to undergo surgical procedures.
Palliative and End-of-Life Care Ezekiel J. Emanuel / Linda L. Emanuel
new chapter on this complex topic provides insights, information, and guidance to practitioners dealing with dying patients and their families
PART THREE, -"GENETICS AND DISEASE,"
Stem Cell and Gene Transfer in Clinical Medicine David Bodine/J. Larry Jameson/Ron McKay
The new chapter on stem cell and gene transfer in clinical medicine addresses a timely and controversial topic, defining different types of stem cells and discussing their potential clinical applications.
PART SIX, "INFECTIOUS DISEASES
Clostridium difficile - Associated Disease, Including Pseudomembranous Colitis Dale N. Gerding/Stuart Johnson
The new chapter offers key information on the management of the complex clinical issues raised by Clostridium difficile-associated disease, including pseudomembranous colitis.
Common Viral Respiratory Infections & Severe Acute Respiratory Syndrome Raphael Dolin
Includes thorough coverage of severe acute respiratory syndrome (SARS).
PART EIGHT, "DISORDERS OF THE CARDIOVASCULAR SYSTEM
ST-Segment Elevation Myocardial Infarction Elliott M. Antman/Eugene Braunwald
A new chapter covers the clinically important topics of unstable angina and non-ST-segment elevation myocardial infarction revised to reflect the latest trends and strategies for management. These include primary percutaneous coronary intervention for ST-segment elevation myocardial infarction as well as new drugs and devices for the treatment of heart failure
PART NINE, "DISORDERS OF THE RESPIRATORY SYSTEM,"
Lung Transplantation Elbert P. Trulock/ G. Alexander Patterson/Joel D. Cooper
a chapter by a new author that focuses on the selection of patients for lung transplantation
Pneumonia Thomas J. Marrie/G. Douglas Campbell/David H. Walker/Donald E. Low
New authors have also taken on the broad topic of pneumonia and lung abscess, providing focus and a clinical perspective to help the reader grasp the central issues involved in the diagnosis and management of both community-acquired and nosocomial disease.
PART TWELVE, "DISORDERS OF THE GASTROINTESTINAL SYSTEM,"
Familial Mediterranean Fever and Other Hereditary Recurrent Fevers Daniel L. Kastner
new chapter on familial Mediterranean fever.
Common Diseases of the Colon and Anorectum and Mesenteric Vascular Insufficiency L. Gearhart/Gregory Bulkley
PART THIRTEEN, "DISORDERS OF THE IMMUNE SYSTEM, CONNECTIVE TISSUE, AND JOINTS,"
Fibromyalgia, Arthritis Associated with Systemic Diseases, and Other Arthritides Bruce C. Gilliland
Covers fibromyalgia, arthritis associated with systemic disease, and other arthritides.
PART FOURTEEN, "Endocrinology and Metabolism
The Menopause Transition and Postmenopausal Hormone Therapy JoAnn E. Manson/Shari S. Bassuk
new chapter on the perimenopause transition and hormone replacement therapy. The writing of the latter chapter coincided with publication of results from the Women's Health Initiative that unexpectedly showed an increased risk of cardiovascular disease among women who received estrogen treatment, provides practical algorithms for the management of patients during this transition.
Disorders of Sexual Differentiation John C. Achermann/J. Larry Jameson
Newer chapter on disorders of sexual differentiation highlight novel insights derived from elucidation of the genetic basis of sex determination.
Wilson Disease George J. Br
new chapter on Wilson's disease reports on the substantially modified treatment recommendations for this entity.
Disorders of Sexual Differentiation John C. Achermann/J. Larry Jameson
Newer chapter on disorders of sexual differentiation highlight novel insights derived from elucidation of the genetic basis of sex determination.
PART FIFTEEN, "NEUROLOGIC DISORDERS
Parkinson's Disease and Other Movement Disorders Mahlon R. DeLong/Jorge L. Juncos
The new chapter on Parkinson's disease reviews the recent genetic findings and provides an authoritative approach to therapy, including surgical options
Prion Diseases Stanley B. Prusiner/Bruce Miller
Finally, the recognition of bovine spongiform encephalopathy in many regions of the world has focused the global health care community on the biology and clinical manifestations of prion diseases; the 16th edition of Harrison's includes a comprehensive review of this subject by Nobel Laureate Stanley Prusiner.
Alzeimer's Disease and Other Dementias Thomas D. Bird/Bruce L. Miller
A comprehensive new chapter on Alzheimer's disease and related dementias summarizes the recent explosion of knowledge on this topic, highlighting the new understanding of the genetics of these dementias and the molecules that trigger them as well as providing a clinical guide to diagnosis, differential diagnosis, and the latest treatments
Cerebrovascular Diseases Wade S. Smith/S. Claiborne Johnston/J. Donald Easton
The chapter on cerebrovascular diseases has been extensively rewritten, offering an evidence-based approach to the treatment and prevention of stroke, the third leading killer in the Western world
Multiple Sclerosis and Other Demyelinating Diseases Stephen L. Hauser/Douglas S. Goode
The updated chapter on multiple sclerosis presents the most recent advances in therapy and a practical approach to management of different stages of the disease.
III. REVISED,REWRITTEN OR CHANGED.
PART 1 INTRODUCTION TO CLINICAL MEDICINE
Women's Health Andrea Dunaif
entirely revised and offers a broad overview of the approach to disorders that affect women disproportionately
PART 2 CARDINAL MANIFESTATIONS AND PRESENTATION OF DISEASES
Sexual Dysfunction Kevin T. McVary
The chapter on sexual dysfunction now addresses disorders in both men and women.
PART 3 GENETICS AND DISEASE (revised)
PART 4 NUTRITION(not much change I presume)
PART 5 ONCOLOGY AND HEMATOLOGY
Principles of Radiation Therapy Stephen M. Hahn/Eli Glatstein
The chapter delineating the principles of radiation therapy has been entirely rewritten by Eli Glatstein and is a companion piece to this author's chapter on radiation bioterrorism
Acute and Chronic Myeloid Leukemia Meir Wetzler/John C. Byrd/Clara D. Bloomfield
Malignancies of Lymphoid Cells James O. Armitage/Dan L. Longo
The hematology section features the World Health Organization's new classification of lymphoid and myeloid neoplasms.
Antiplatelet, Anticoagulant, and Fibrinolytic Therapy Steven R. Deitcher
With development of novel agents to interfere with blood coagulation, the chapter on anticoagulant, fibrinolytic, and antiplatelet therapy reviews all these new products and their indications.
PART 6 INFECTIOUS DISEASES
Viral Gastroenteritis Umesh D. Parashar/Roger I. Glass
Staphylococcal Infections Franklin D. Lowy
Brucellosis Michael J. Corbel/Nicholas J. Beeching
The latest advances in the management of diseases caused by staphylococci and nontuberculous mycobacteria, viral gastroenteritis, and brucellosis have been added.
Common Viral Respiratory Infections & Severe Acute Respiratory Syndrome Raphael Dolin
The superb chapter by Raphael Dolin on common viral respiratory infections has been expanded to include thorough coverage of severe acute respiratory syndrome (SARS).
Human Immunodeficiency Disease: AIDS and Related Disorders Anthony S. Fauci/H. Clifford Lane
Now placed in a separate section with the overview of the human retroviruses, the chapter on HIV infection and AIDS by Anthony S. Fauci and H. Clifford Lane has been completely revised and updated, with an emphasis on therapeutic strategies. This chapter is widely considered to be a classic in the field.
PART 9 DISORDERS OF THE RESPIRATORY SYSTEM
New authors have taken on the broad topic of pneumonia and lung abscess, providing focus and a clinical perspective to help the reader grasp the central issues involved in the diagnosis and management of both community-acquired and nosocomial disease.
PART 12 DISORDERS OF THE GASTROINTESTINAL SYSTEM
Approach to the Patient with Gastrointestinal Disease William L. Hasler/Chung Owyang
The chapter on the approach to the patient with gastrointestinal disease has been completely reworked by a new author
Acute Viral Hepatitis Jules L. Dienstag/Kurt J. Isselbacher
Toxic and Drug-Induced Hepatitis Jules L. Dienstag/Kurt J. Isselbacher
Chronic Hepatitis Jules L. Dienstag/Kurt J. Isselbach
The SE chapters on the various categories of viral hepatitis have been extensively revised and updated to reflect breakthrough advances in treatment.
PART 13 DISORDERS OF THE IMMUNE SYSTEM, CONNECTIVE TISSUE, AND JOINTS
Disorders of Immune-Mediated Injury
In the section on disorders of immune-mediated injury, the spondyloarthropathies have been grouped together in one chapte discusses the similarities and dissimilarities among the various diseases in this category
Autoimmunity and Autoimmune Diseases Peter E. Lipsky/Betty Diamond
Includes the advances in immunomodulatory therapy that have been realized in rheumatology over the past few years
Systemic Lupus Erythematosus Bevra Hannahs Hahn
Rheumatoid Arthritis Peter E. Lipsky
the extensively revised chapters on rheumatoid arthritis and systemic lupus erythematosus.
PART 14 ENDOCRINOLOGY AND METABOLISM
Bone and Mineral Metabolism in Health and Disease F. Richard Bringhurst/Marie B. Demay/Stephen M. Krane/Henry M. Kronenberg
outstanding new review of bone and mineral metabolism
Disorders of Lipoprotein Metabolism Daniel J. Rader/Helen H. Hobbs
chapter on disorders of lipoprotein metabolism offers a much sharper focus on the classification, diagnosis, and treatment of disorders of cholesterol and triglyceride metabolism, emphasizing the use of statins for the reduction of cardiovascular risk.
PART 15 NEUROLOGIC DISORDERS
Cerebrovascular Diseases Wade S. Smith/S. Claiborne Johnston/J. Donald Easton
The chapter on cerebrovascular diseases has been extensively rewritten, offering an evidence-based approach to the treatment and prevention of stroke, the third leading killer in the Western world
Multiple Sclerosis and Other Demyelinating Diseases Stephen L. Hauser/Douglas S. Goode
The updated chapter on multiple sclerosis presents the most recent advances in therapy and a practical approach to management of different stages of the disease.
PART 16 POISONING, DRUG OVERDOSE, AND ENVENOMATION(revised)
IV.CATEGORICAL CHANGES.
PART 6 INFECTIOUS DISEASES
Human Immunodeficiency Disease: AIDS and Related Disorders Anthony S. Fauci/H. Clifford Lane
Now placed in a separate section with the overview of the human retroviruses, the chapter on HIV infection and AIDS by Anthony S. Fauci and H. Clifford Lane has been completely revised and updated, with an emphasis on therapeutic strategies. This chapter is widely considered to be a classic in the field.
PART 13 DISORDERS OF THE IMMUNE SYSTEM, CONNECTIVE TISSUE, AND JOINTS
Disorders of Immune-Mediated Injury
In the section on disorders of immune-mediated injury, the spondyloarthropathies have been grouped together in one chapte discusses the similarities and dissimilarities among the various diseases in this category
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