Q)The following is true about drug induced lupus:
a) hypocomplementinemia present
b) renal involvement occurs invariably
c) ANA disappears as soon as the offending drug is withdrawn
d) anti histone +ve
Reference:Harrisons 15th ed pg 1926
Drug induced lupus is charcterised by:
- Though the offending drug induces ANA in most (50-75%) cases,only 10-20% of ANA +ve individuals develop lupus-like syndrome.
- Renal and CNS involvment is rare.
- Antibodies to ds-DNA & hypocomplementinemia rare(distinguishing feature).
- Anti histone is +ve.
- Most patients improve in few weeks,on withdrawing the offending drug,but ANA may persist for years.
wrong option;hypocomplementinemia isn’t seen in drug induced lupus.
b)renal involvement occurs invariably:
renal and CNS involvment rare;wrong option
c)ANA disappears as soon as the offending drug is withdrawn:
ANA persists for years,even after withdrawing the offending drug.
d)anti histone +ve: correct option.
correct choice:(d) anti histone +ve
1)Most specific for SLE : a)Anti ds DNA
2)Anti La(ss-B) : Sjogren’s syndrome(low risk of nephritis).
3)Anti Ro : Neonatal lupus
old age lupus
ANA –ve lupus
congenital heart block
4)Most common offending drug in drug induced lupus is procainamide.
Source of this Question: RxPG DNB 2004
Author : Dr. Rashmi Yadav
Publisher: Jaypee Brothers Medical Publishers, India
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