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Pharmacology Question Busters
Pharmacology Section - Pharmacology MCQ Bank Forum - Pharmacology Books
Ionisation of a drug
by RxPG - 3689 reads, based on 12 votes
Question. The extent to which ionisation of a drug takes place is dependent upon pKa of the drug and the pH of the solution in which the drug is dissolved. which of the following statements is not correct. 1.pKa of a drug is the pH at which the drug is 50% ionized. 2.Small changes of pH near the pKa of a weak acidic drug will not affect its degree of ionisation. 3.Knowledge of pKa of a drug is useful in predicting its behaviour in various body fluids. 4.Phenobarbitone with a pKa of 7.2 is largely ionized at acid pH and will be about 40% non-ionised in plasma.... More

Bioavailability of a drug
by RxPG - 3766 reads, based on 8 votes
All of the following statements regarding bioavailability of a drug are true except: 1. It is the proportion (fraction) of unchanged drug that reaches the systemic circulation. 2. Bioavailability of an orally administered drug can be calculated by comparing the Area Under Curve (0- ) after oral and intravenous (iv) administration. 3.Low oral bioavailability always and necessarily mean poor absorption. 4.Bioavailability can be determined from plasma concentration or urinary excretion data.... More


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