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Psychiatry Drug Reviews
Psychiatry Section - Psychiatry Study Group - MCQs, Notes, Study Tips and Strategies Forum - Psychiatry Books


Donepezil - centrally acting reversible acetyl cholinesterase inhibitor
by wikipedia - 4212 reads, based on 1 vote
Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a half life of about 70 hours, it can be taken once a day. Initial dose is 5 mg per day, which can be increased to 10 mg per day after an adjustment period of at least 4 weeks.... More

Olanzapine - Thienobenzodiazepine Atypical Antipsychotic
by wikipedia - 16124 reads, based on 7 votes
Olanzapine was the second atypical antipsychotic to gain FDA approval and has become one of the most commonly used atypical antipsychotics. Olanzapine has been FDA approved for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder. Olanzapine can also be used to treat anxiety, although it is not commonly recommended for that purpose due to the strong side effects and expense. In particular, unlike benzodiazapenes, antipsychotics are non-addictive. Some psychiatrists have also been known to prescribe it to eating disorder patients, due both to its mood stabilising effects ... More

Risperidone - Most Commonly Used Atypical Antipsychotic
by wikipedia - 5570 reads, based on 4 votes
Risperidone is an atypical antipsychotic medication. It is most often used to treat delusional psychosis (including schizophrenia), but risperidone (like other atypical antipsychotics) is also used to treat some forms of bipolar disorder and psychotic depression. It also has shown some success in treating symptoms of Asperger's Syndrome and autism. Generally lower doses are used for autistic spectrum disorders than are used for schizophrenia and other forms of psychosis, although risperidone has not yet been officially approved by the FDA for the treatment of autism and Asperger's.... More

Clozapine - The First Atypical Antipsychotic
by wikipedia - 7787 reads, based on 3 votes
Clozapine, approved by the FDA in 1989, was the first of the atypical antipsychotics. Clozapine is the only FDA approved medication indicated for treatment-resistant schizophrenia and for reducing the risk of suicidal behaviour in patients with schizophrenia. Clozapine was developed by Sandoz in 1961, and introduced in Europe ten years later. In 1975, after reports of agranulocytosis leading to death in some clozapine-treated patients, Clozapine was voluntarily withdrawn by the manufacturer. Clozapine fell out of favor for more than a decade. However, when studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics, the FDA and h... More

Quetiapine - D1 and D2 dopamine antagonist
by wikipedia - 5570 reads, based on 1 vote
Quetiapine (kwe-TYE-a-peen) is one of the atypical antipsychotics. Quetiapine has FDA and international approvals for the treatment of schizophrenia and acute mania in bipolar disorder. It is used "off-label" to treat other disorders, such as post-traumatic stress disorder, obsessive compulsive disorder, anxiety disorders, and as a sedative for those with sleep disorders. The typical effective dose is between 300 and 600 mg daily given at bedtime or in divided doses during the day.... More

Ziprasidone - The Atypical Amongst Atypical Antipsychotics
by wikipedia - 3574 reads, 0 votes
Ziprasidone was the fifth atypical antipsychotic to gain FDA approval. Ziprasidone is FDA approved for the treatment of schizophrenia, and the intramuscular injection form of Ziprasidone is approved for acute agitation in schizophrenic patients. "Unlabeled" uses include treatment of bipolar disorder.... More

Aripiprazole - First Second Generation Atypical Antipsychotic
by Emmanuel - 3844 reads, based on 9 votes
DRUG CLASS AND MECHANISM: Aripiprazole is an anti-psychotic drug for treating psychoses. Like other anti-psychotic drugs, the mechanism of action of aripiprazole is unknown. Moreover, like other anti-psychotics, it blocks several receptors on the nerves of the brain for several neurotransmitters (chemicals that nerves use to communicate with each other). It is thought that its beneficial effect is due to its effects on dopamine and serotonin receptors. Its effects on these receptors are complex, involving stimulation of the receptors but to a lesser degree than the naturally-occurring neurotransmitters (a process called partial agonism). The FDA approved aripiprazole as a treatment for schiz... More


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