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Quick Scroll associated with this leukemia? 04.11.05 (3 years ago) #1
A 50-year-old woman presents to her physician with fatigue and a 30 lb weight loss. A peripheral smear and bone marrow biopsy demonstrate a leukemia composed of cells in the neutrophil, eosinophil, and basophil lineages. No blast forms are seen. Which of the following is
associated with this leukemia?



Options:bbc

A. bcl-2 activation.

B. c-myc activation.

C. t(8, 14)

D. t(9, 22)

E. t(14,18)
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Quick Scroll 04.13.05 (3 years ago) #2
The correct answer is D.

The disease is chronic myelogenous leukemia (CML), which usually affects adults between 40 and 59 years of age. CML is associated with the Philadelphia chromosome, which is actually a translocation involving chromosomes 9 and 22 that produces an abl-bcr hybrid.

bcl-2 activation (choice A) and a t(14,18) (choice E) translocation are features of follicular lymphomas.

c-myc activation (choice B) and a t(8,14) (choice C) translocation are features of Burkitt's lymphoma.
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