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trinitySend an Instant Message to trinity  




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Quick Scroll covalent interaction with target ? 11.07.05 (2 years ago) #1
which of teh following drugs has a covalent interaction with its target??

1) aspirin

2) penicillin

3) nitric oxide

4) bosentan

anyone?
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Quick Scroll 11.07.05 (2 years ago) #2
aspirin
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Quick Scroll 11.07.05 (2 years ago) #3
u r rite drkp.
no confusions over this one...
the ans is aspirin
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Quick Scroll 11.08.05 (2 years ago) #4
aspirin it is
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Quick Scroll 11.08.05 (2 years ago) #5
i think it is penicillin
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Quick Scroll 11.08.05 (2 years ago) #6
i think it is penicillin
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Quick Scroll 11.08.05 (2 years ago) #7
this is because penicillin binds covalently with penicillin binding proteins
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Quick Scroll 11.08.05 (2 years ago) #8
this is because penicillin binds covalently with penicillin binding proteins
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Quick Scroll 11.09.05 (2 years ago) #9
answer should be aspirin as usual.
recall that for aspirin toxicity , the reversal takes 7 days --> duration for replenishment of fresh platelets.
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Quick Scroll 11.09.05 (2 years ago) #10
can any one give the reference for this non competetive inhibition of COX by aspirin is a covalent one?
i wasn't able to find it out in our books (tripathy, harrison)
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