Page 1 of 1: very simple question as i guess

shabana · Credits: 11520 My Scrapbook

please, i want to know what is the meaning of partial agonist i want good explanation (and if possible exampls) and can we give adrenaline iv infusion? and in which cases?

npshades · Credits: 809 My Scrapbook

hi friend
i am giving the notes about partial agonists

HOPE U WILL UNDERSTAND IT VERY WELL
Pharmacodynamics, or how the plasma concentration of a drug translates into its effect on the body, depends on biologic variability, receptor Physiology , and clinical evaluations of the actual drug. An agonist is a drug that causes a response. A full agonist produces the full tissue response, and a partial agonist provokes less than the maximum response induced by a full agonist.

SOME MORE NOTES ABOUT AGONISTS

Based on the maximal pharmacologic response that occurs when all receptors are occupied, agonists can be divided into two classes: partial agonists produce a lower response, at full receptor occupancy, than do full agonists. Partial agonists produce concentration-effect curves that resemble those observed with full agonists in the presence of an antagonist that irreversibly blocks some of the receptor sites .It is important to emphasize that the failure of partial agonists to produce a maximal response is not due to decreased affinity for binding to receptors. Indeed, a partial agonist's inability to cause a maximal pharmacologic response, even when present at high concentrations that saturate binding to all receptors, is indicated by the fact that partial agonists competitively inhibit the responses produced by full agonists .Many drugs used clinically as antagonists are in fact weak partial agonists.

I HOPE U UNDERSTAND IT WELL

DEAR I PROVIDED THE NOTES FOR U ABOUT THE INTRAVENOUS USE OF ADRENALINE IN MY LAST POST
PLEASE REFER THAT
TAKE CARE AND HAVE A GREAT TIME
BYE
NPSHADES

npshades · Credits: 809 My Scrapbook

WE FIND SOME GOOD EXAMPLES ABOUT PARTIAL AGONISTS IN OPOID GROUP OF DRUGS!

PENTAZOCIANE IS ONE SUCH DRUG

U CAN GET A GOOD NOTES IF U READ KATZUNG!!!!!

TAKE CARE AND HAVE A GREAT DAY

spatil · Credits: 2263 My Scrapbook

Adrenaline can be given by IV route in shock in dose of 1:10000. watch for arrythmia. Adrenaline used in 1:1000 for Im route which is generally prefered

shabana · Credits: 11520 My Scrapbook

thanks alot

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