Page 1 of 1: mcq "4"

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Question 1. Indicate which of the following observations contradict Mendel's laws.

a) autosomal recessive inheritance.
True False

b) uniparental disomy.
True False

c) chromosome segregation at meiosis.
True False

d) genetic linkage.
True False

e) polygenic inheritance.
True False

Question 2. Standard chromosome analysis:

a) is best achieved during interphase.
True False

b) identifies all chromosome abnormalities.
True False

c) involves use of electron microscope.
True False

d) takes at least 3 days.
True False

e) is usually carried out using red blood cells.
True False

Question 3. Indicate which of the following statements are true.

a) Chromosomes are composed of DNA and histone proteins only.
True False

b) The polynucleotide chains of DNA are orientated in a parallel fashion.
True False

c) In DNA the purine nucleotide adenine (A) normally pairs with the pyrimidine nucleotide cytosine (C).
True False

d) The pentose sugar of mRNA is ribose.
True False

e) The genetic code is termed degenerate as is it overlapping.
True False

Question 4. Meiosis:

a) results in halving of the diploid number.
True False

b) does not involve the X and Y chromosomes.
True False

c) involves recombination between homologous chromosomes.
True False

d) takes longer in males than in females.
True False

e) leads to a high incidence of abnormal liveborn offspring in carriers of balanced paracentric inversions.
True False

Question 5. Indicate which of the following statements are true.

a) mRNA in the cytoplasm is in the same form as in the nucleus of the cell.
True False

b) The genetic code is the same in all mammalian cellular organelles.
True False

c) Genes which are not expressed are called pseudogenes.
True False

d) Transcription is the transfer of genetic information from RNA to protein.
True False

e) Structural genes constitute the majority of the DNA in the human genome.
True False

Question 6. Indicate which of the following statements are true.

a) Most mutations in genes occur within the nucleotide recognition sequence of a restriction enzyme.
True False

b) Dinucleotide (CA) repeats are frequently used in linkage studies for carrier testing and prenatal diagnosis.
True False

c)Single stranded conformational polymorphism (SSCP) is a mutation testing method.
True False

d) The polymerase chain reaction can only be used with large quantities of DNA.
True False

e) Linked probes can be used clinically in carrier testing, predictive testing or prenatal diagnosis before the gene responsible has been cloned.
True False

Question 7. Achondroplasia:

a) is caused by mutations in FGFR3.
True False

b) is caused by mutations with a loss-of-function effect.
True False

c) is associated with severe learning difficulties.
True False

d) shows X-linked recessive inheritance.
True False

e) is more severe in homozygotes than in heterozygotes.
True False

Question 8. Monozygotic twins:

a) result from the division of a single ovum fertilised by two sperm.
True False

b) would be expected to show close to 100% concordance for Down's syndrome.
True False

c) are a frequent cause of chimerism.
True False

d) can donate organs to each other without any risk of rejection.
True False

e) provide a valuable resource for study of the effects of gene-environment interaction.
True False

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