Page 1 of 1: Acanthosis nigricans is caused by which drug

dr_nickash · Credits: 6817 My Scrapbook

Acanthosis nigricans is caused by which drug
a) Amphotericin-B
b) Ketoconazole
c) Nicotinic acid.....a
d) Nalidixic acid.

moujik · Credits: 877 My Scrapbook

i think the ans will b nicotinic acid,'cause it causes hyperpigmentation.

neelanjana · Credits: 2096 My Scrapbook

Acanthosis nigricans-like eruption

Corticosteroids, Hydantoin, Nicotinic Acid, Pills, Stilbestrol

Acneiform eruption

Anticonvulsant (phenytoin, phenobarbital, trimethadione), Antituberculous (isoniazid, ethionamide, refampicin), Azathioprine, Chloral hydrate, Corticosteroids, Corticotropin (ACTH), Cyanocobalamin, Cyclosporin, Halogens (bromides, chlorides, iodides, halothane), Haloperidol, Lithium, Pills, Psoralens, Quinine, Scopolamine

Acral erythema/red palms

Adriamycin (Doxorubicin), Cystosine arabinoside, 5-fluorouracil

Acrodynia

Mercury

Alopecia

Allopurinol, Bromocriptine, Carbimazole, Chlorambucil, Chloramphenicol, Cholesterol lowering agents, Cimetadine, Colchicine, Coumarin, Cytotoxic drugs, Diazoxide, Ethionamide, Fluconazole, Gentamicin, Gold, Heavy metals, Heparin, Hydantoin, Levodopa, Methotrexate, Methyldopa, NSAID (indomethacin, piroxicam), Pills, Phenindione, Propanolol, Sodium valproate, Thiouracil, Vitamin A or Retinoids

Anaphylactic Reaction

Acetylsalicylic acid, ACTH, Aminopyrine, Meprobamate, Mercurial Diuretics, Para-aminosalicylic Acid, Penicillin, Pituitary Extract, Procaine, Succinylcholine, Tetracycline, Thiouracil

Angiitis, Necrotizing

Bishydroxycoumarin (Dicumarol)

Angioedema

Meprobamate, Penicillin, Stilbestrol, Sulfonamides

Argyria

Silver Salts

Arteritis

Cyclobarbital, Chlorpromazine, Iodides, Phenylbutazone, Phenytoin, Poison Ivy Extract, Sulfonamides, Thiouracil

Black hairy tongue

Tetracycline, Penicillin

Bowen's Disease

Arsenic, Fowler's Solution

[bleep] eruption

Acetylsalicylic acid, Antipyrines, Arsenic, Barbiturates, Bromide, Chloral hydrate, Chlorpromazine, Coumarin, Dilantin, Glutethimide, Hydantoin derivatives, Ibuprofen, Imipramine, Iodide, Phenobarbital, Phenylbutazone, Promethazine, Methadone, Meprobamate, Nitrazepam, Sulfonamides

Candidiasis

Tetracyclines

Chilblains-like erythema

Coumarins, Phenindione, Sulindac

Cyanosis

Acetanilide

Depigmentation

Chloroquine

Eczematous reactions (other than contact eczema)

Aminophylline, Antibiotics, Antihistamine, B-blockers, Benzocaine, Bleomycin, Carbamazepine, Chloral Hydrate, Diphenhydramine, Disulfuram, Fluorouracil, Fucidin, Meprobamate, Methaminodiazepoxide, Minoxidil, Neomycin, Nystatin, Phenothiazines, Procainamide, Procaine, Quinacrine, Quinidine, Resorcin, Streptomycin (cross-reaction with neomycin), Sulphonamide, Thiazide

Edema

Arsenic, Chlorpromazine, Penicillin, Phenytoin, Promethazine, Chloroquine

Elastosis perforans serpiginosa

Penicillamine

Erythema/exanthem

Allopurinol, Ampicillin, Antipyrines, Arsenic, Atropine, Aurothioglucose, Barbiturates, Carbamazepine, Chloral hydrate, Chlorpropamide, Codeine, Corticotropin, Gentamicin, Gold, Griseofulvin, INH, Interleukin-2, Meprobamate, Methaminodiazepoxide, Morphine, Nicotinic Acid, Nitrofurantoin, Opium, Penicillin, Phenothiazine, Phenylbutazone, Pilocarpine, Quinacrine, Quinidine, Quinine, Streptomycin, Sulphonamides, Sulphamethoxypyridazine, Thiazide, Thiamine Chloride, Tolbutamide

1) Maculopapular rash

Allopurinol, Chloroquine, Meprobamate, Penicillin, Promethazine, Streptomycin, Sulfamethoxypyridazine

2) Morbilliform erythema

Acetylsalicylic acid, Ampicillin, Barbiturates, Bromides, Chlorpromazine, Griseofulvin, Insulin, Meprobamate, Penicillin, Promethazine, Salicylates, Streptomycin

3) Scarlatiniform erythema

Barbiturates, Mercury, Morphine, Opium, Penicillin, Phenobarbital, Pituitary Extract, Quinine, Salicylates, Streptomycin, Sulfonamides

4) Toxic erythema

Drugs most commonly responsible (up to 5% of patients affected):

Allopurinol, Carbamazepine, Cephalosporins, Gold, Nalidixic acid, Penicillins, Sulphonamides

Other drugs commonly responsible (1-4% of patients affected):

Isoniazid, Para-amino salicylic acid, Phenytoin, NSAIDs, Nitrofurantoin, Streptomycin

Erythema multiforme (including Stevens-Johnson syndrome and toxic epidermal necrolysis)

Acetylsalicylic acid, Allopurinol, Amidopyrine, Antihistaminics, Anti-pyrines, Barbiturates, Bromides, Carbamazepine, Chloral hydrate, Cimetadine, Corticotropin (ACTH), Furosemide, Griseofulvin, Hydantoins, Iodides, Mercury, NSAIDs (especially piroxicam), Para-aminosalicyclic Acid, Penicillins, Phenytoin, Phenolphthalein, Phenothiazine, Phenyl-butazone, Procaine, Streptomycin, Sulfamethoxy-pyridazine, Sulphonamides, Tetracycline

Erythema Nodosum

Acetylsalicylic Acid, Bromides, Gold, Iodides, Penicillin, Phenacetin, Pills, 13-cis-retinoic acid, Salicylates, Sulfathiazole, Tetracycline

Erythroderma (Exfoliative dermatitis)

Allopurinol, Aminosalicylic Acid, Arsenicals, Aurothioglucose, Barbiturates, Bismuth, Captopril, Carbamazepine, Cefoxitin, Chlorpromazine, Chloroquine, Cimetadine, Dapsone, Diltiazem, Gold, Griseofulvin, Hydantoin, Iodides, Isoniazid, Lithium, Mercury, Nitrofurantoin, NSAID, Penicillin, Phenothiazines, Phenytoin, Quinidine, Quinacrine, Sodium Thiosulfate, Stilbestrol, Streptomycin, Sulphamethoxypyridazine, Sulphonamides, Sulphonylurea, Tetracycline, Thiouracil, Retinoid

Erythromelalgia

Bromocriptine, Nifedipine, Pergolide, Verapamil

Fixed drug eruption

Aminopyrine, Amphetamines, Antihistaminics, Antimony Compounds, Antipyrines, Arsenic, Barbiturates, Bismuth, Chlordiazepoxide, Chloral Hydrate, Chloroquine, Codeine, Dapsone, Gold, Diethylstilbestrol, Digitalis, Ephedrine, Ergot, Hydantoin, Hydralazine, Iodides, Meprobamate, Mercury, Metronidazole, Morphine, NSAIDs, Opium, Para-aminosalcylic acid, Paracetamol, Penicillin, Phenacetin, Phenolphthalein, Phenothiazine, Phenylbutazone, Potassium Chlorate, Quinacrine, Quinine, Reserpine, Salicylates, Streptomycin, Sulfonamides, Sulindac, Tetracyclines, Tetraiodofluorescein

Gangrene

Coumarin

Gingival hyperplasia

Cyclosporin, Nifedipine, Hydantoin

Hair color changes

Carbamate, Chloroquine, Chlorpromazine

Henoch-shonlein purpura-like eruption

Diltiazem, Frusemide

Hirsutism/hypertrichosis

Acetazolamide, Anabolic agents, Bromocryptine, Chlorobenzene, Corticosteroid, Cyclosporin, Cyproterone, Danazol, Diazoxide, Digoxin, Diphenylhydantoin, Dyazide, Metyrapone, Minoxidil, Penicillamine, Phenothiazine, Progestogens, Psoralens, Spironolacton, Streptomycin

Ichthyosis, acquired

Butyrophenone, Nicotinic acid, Triparanol

Jaundice

Aurothioglucose, Erythromycin lauryl sulphate, Para-aminosalicylic Acid, Phenobarbital, Thiouracil

Keratoderma

Gold

Keratoses

Arsenic, Fowler's Solution, Gold

LE-like syndrome

Acebutolol, Allopurinol, Aminoglutethimide, Aminosalicylic acid, Captopril, Carbamazepine, Chlorpromazine, Cimetidine, Ethosuximide, Gold, Griseofulvin, Hydantoin, Hydralazine, Isoniazid, Labetolol, Lithium, Mephobarbital, Methyldopa, Minocycline, Penicillin, Phenylbutazone, Phenytoin, Pill, Practolol, Procainamide, Reserpine, Streptomycin, Sulfamethoxypyridazine, Sulphonamide, Tetracycline HCI (degraded), Thiazide, Thionamide, Thiouracil

Lichenoid eruption

Beta-blocker (Practolol), Bismuth, Captopril, Carbamazepine, Chloroquine, Cholorpropamide, Gold, Hydroxyurea, Meprobamate, Mepacrine, Methyldopa, para-amino-salicyclic acid, Penicillamine, Phenothiazine, Quinine, Quinidine, Streptomycin, Sulphonylurea, Tetracycline, Thiazides

Linear Ig-A dermatosis

Amiodarone, Captopril, Cefamandole, Diclophenac, Lithium, Vancomycin

Livedo reticularis

Amantadine

Lymphoproliferative disease/Pseudolymphoma

ACE-inhibitor, Carbamazepine, Cyclosporin, Dantrolene, Diltiazem, Hydantoin, Pyrazolone, Pyrimethamine

Mucosal ulcerations, oral

Foscarnet, DDC, Interferon

Nail changes

Amodiaquin (hyperpigmentation), arsenic (longitudinal white stripes), argyria (dark blue nail bed), Chloroquine (blue-black nail bed), Phenolphthalein (dark blue fixed eruption), tetracycline (yellow nail and yellow fluorescence), demethylchlortetracycline (phototoxic onychomadesis)

Ochronosis-like pigmentation

Phenol, Quinacrine, Resorcin

Onycholysis

Demethylchlortetracycline

Papular dermatitis

Acetazolamide, Acetylsalicylic acid, Arsenic, Aurothioglucose, Digitalis, Penicillin, Thiazide

Pellagra-like eruption

Isoniazide

Pemphigoid-like eruption

1) [bleep]

5-Fluorouracil (topical), Frusemide, Ibuprofen, Penicillamine, Penicillin, Sulphasalazine, PUVA

2) Cicatrical

Anti-glaucoma agent (topical), Clonidine, Indomethacin, D-penicillamine, Practolol, Sulphadoxine

Pemphigus-like eruption

Ampicillin, Captopril, Enalapril, Pencillamine, Penicillin, Phenylbutazone, Pyrazolan derivative, Rifampicin, Sulphydryl groups (pyritinol, thiopronin)

Photosensitivity

Amiodarone, Chlorthiazide, Chlorpromazine, Chlorpropamide, Cytotoxic (Dacarazine, Methotrexate, Fenofibrate, Fluorescein, 5-fluorouracil, Furocoumarins, Griseofulvin, Nalidixic acid, NSAID (benoxaprofen, piroxicam, naproxen), Phenothiazine, Promethazine, Psoralen (Methoxsalen, Trimethylpsoralen), Quinidine, Quinine, Quinolones, Reserpine, Retinoids, Sulphonamides, Sulphonylureas, Sunscreen (PABA, oxybenzone), Tetracyclines (demeclotetracycline, doxycycline, tetracycline), Tolbutamide, Tricyclic antidepressant (Clomipramine, Carbamazepine)

Pigmentation

Amiodarone (slatey grey pigmentation on light-exposed skin)

Antimalarials (diffuse generalized grey/brown pigmentation; mepacrine causes generalized yellow/orange discoloration resembling jaundice

Antipyrines, Bismuth (gums)

Clofazimine

Chlorpromazine (slate-colored)

Chloroquine (bleaching of hair)

Cytotoxic drugs (busulphan, bleomycin, cyclophosphamide, fluorouracil, hydroxyurea, may cause generalized brown pigmentation)

Gold/silver (chrysiasis) blue/grey pigmentation on light-exposed skin)

Minocycline hydrochloride (blue/grey pigmentation on light-exposed skin and in scars)

Oral contraceptives (melasma -brownish pigmentation on face)

Phenformin (brown pigmentation on light-exposed skin)

Phenothiazines (bluish pigmentation on light-exposed skin, especially on the face)

Phenytoin (melasma-like pigmentation on face)

Streptomycin, Tetracosactide, Tetracyclines, Thiouracil

Zidovudine (AZT) (melanonychia, diffuse cutaneous/oral mucosal pigmentation, acral hyperpigmented macules)

Pityriaisis rosea-like eruption

Arsenicals, Bismuth, Gold, Barbiturates, Clonidine, Captopril, Isotretinoin, Ketotifen, Methoxypromazine, Metronidazole, Pyribenzamine

Polyarteritis nodosa-like eruption

Sulfonamides, Thiouracil, Iodides

Porphyria

(Drugs provoke variegate porphyria):

Alcohol, Androgens, Barbiturates, Carbamazepine, Chlordiazepoxide, Chloroquine, Griseofulvin, Hexachlorobenzene, Hydantoin, Meprobamate, Nortriptyline, Pills, Oestrogens, Sodium valproate, Sulphonamides, Sulphonylureas

(Drugs provoke porphyria cutanea tarda):

above + Busulphan, Quinidine, Quinine, Rifampicin

Pseudo-porphyria

Amiodarone, Bumetamide, Ciprofloxacin, Frusemide, Nalidixic aid, NSAID, Ofloxacin, Tetracycline

Pruritus

Alkaloid, Antidepressive, Antimalarial, Atropine, Aurothioglucose, Barbiturates, Belladonna, Bismuth, Cimetadine, CNS stimulant, Cocaine, Codeine, Coumarin, Griseofulvin, Heparin, Insulin, Iodide, Niacinamide, Opiates, Penicillin, Phenobarbital, Procaine, Quinacrine, Streptomycin, Tetracyclines, Thiamine Chloride, Thiouracil

Pruritus ani

Chloroquine, Codeine, Liver Extract, Tetracyclines

Purpura

ACTH, Allopurinol, Barbiturates, Carbromal, Chlorpromazine, Corticosteroids, Coumarin, Ephedrine, Griseofulvin, Iodide, Meprobamate, Mercury, Penicillin, Quinidine, Reserpine, Sodium thiosulfate, Sulfamethoxypyridazine, Sulfonamides, Thiazides

Purpura Fulminans

Acetylsalicylic acid, Coumarin, Iodides

Pustular Psoriasis

Acetylsalicylic Acid, Antimalarials, Poliomyelitis vaccine

Pustuloderma

Bromides, Chloral hydrate, Iodides, Penicillin, Macrolide

Seborrhoeic dermatitis

Methyldopa, Phenothiazines

Scleroderma-like eruption

Epoxy resin monomer, Organic solvent, Perchlorethylene, Trichlorethylene, Vinyl chloride monomer

Bleomycin, Carbidopa, Penicillamine, Pentazocine, Organic solvent, Sodium valproate, Injection of paraffin or silicone

Stevens-Johnson Syndrome

Allopurinol, Antipyrines, barbiturates, Chlormezanone, Chloroquine, Chlorpropamide, Cotrimoxazole, Cough Mixtures, Meprobamate, NSAID, Phenacetin, Phenobarbital, Phenytoin, Sulfonamides

Stomatitis

Aurothioglucose, Bismuth, Chlorpromazine, Dilantin (gingivitis), Fluorides, Methotrexate, Phenobarbital, Streptomycin, Thiouracil

Striae

Corticosteroids, Isoniazid

Telangiectasia

Oral contraceptives

Toxic Epidermal Necrolysis

Acetazolamide, Allopurinol, Aminopyrine, Antihistaminics, Anti-pyrines, Barbiturates, Brompheniramine, Dapsone, Gold Salts, Methyl-salicylate, Nitrofurantoin, Penicillin, Phenolphthalein, Phenylbutazone, Phenytoin, Salicylates, Polio Vaccine, Sulfonamides, Tetracyclines, Tolbutamide

Urticaria

1) Immunological mediation

Drugs most commonly responsible:

Enzymes, Penicillins, Pollen vaccines, Polypeptide hormone, Serum, Sulphonamides

Other drugs responsible, but lower incidence:

Barbiturate, Carbimazole, Cephalosporins, Cimetidine, Griseofulvin, Insulin, Metronidazole, Phenytoin, Quinidine, Synthetic adrenocorticotrophin, Tetracycline

2) Non-immunological mediation

Alcohol, Aspirin and other salicylates, Atropine, Chlortetracycline, Codeine, Dextran, Decamethonium, Morphine, NSAID, Oestrogen, Pilocarpine, Polymyxin antibiotics, Quinine, Radiographic contrast media, Scopolamine, Snake venoms, Thiamine, d-Tubocurare, Vancomycin

Vasculitis

Anti-influenza, vaccine, Allopurinol, Arsenic, Captopril, Chlorpromazine, Cimetidine, Clindamycin, Corticosteroids, Ethacrynic acid, Gold, Griseofulvin, Guanethidine, Heparin, Hydantoin, Hydralazine, Indomethacin, Insulin, Iodide, Ketoconazole, Methylthiouracil, Penicillin, Phenothiazine, Phenylbutazone, Phenytoin, Pill, Poison ivy extract, Quinidine, Serum, Streptomycin, Streptokinase, Sulphonamides, Tamoxifen, Tetracycline, Thiazide, Thiouracil, Vancomycin

SO ANSWER IS NICOTINIC ACID!

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