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jayanta
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OBSTETRICS-TUMOR
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07.16.06 (2 years ago)
#1
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OVARIAN TUMOR WITH VIRILISATION IS:
1.GRANULOSA TUMOR.
2.SERTOLI-LEYDIG TUMOR.
3.TERATOMA.
4.GONADOBLASTOMA.
ANSWER GIVEN IS [2].
BUT WHAT IS THE SERTOLI-LEYDIG TUMOR,FRIEND?
I HAVE NO IDEA.
REGARDS.
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vimoj
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Re: OBSTETRICS-TUMOR
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07.16.06 (2 years ago)
#2
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| jayanta wrote: |
OVARIAN TUMOR WITH VIRILISATION IS:
1.GRANULOSA TUMOR.
2.SERTOLI-LEYDIG TUMOR.
3.TERATOMA.
4.GONADOBLASTOMA.
ANSWER GIVEN IS [2].
BUT WHAT IS THE SERTOLI-LEYDIG TUMOR,FRIEND?
I HAVE NO IDEA.
REGARDS. |
SERTOLI-LEYDIG CELL TUMOR/ANDROBLASTOMA- the main points
-very rare ovarian tumor
-grouped in the sex cord-stromal cell tumors
-known for producing various hormones and about 1/3 of cases may present with virilization.
- other patients, oligomenorrhea followed by amenorrhea may occur.
-Progressive masculinization and hirsuitism may also occur.
-However, 50% of these patients may have no endocrine symptomatology and instead have abdominal pain or swelling.
-Removal of the tumor results in a nomral menses in about 4 weeks.
- MEAN AGE -Mean 25 years
75%<30 years
- INCIDENCE- >0.5% of all ovarian tumors
INVESTIGATIONS
-Elevated levels of testosterone, androstenedione
-ELEVATED Urine 17-ketosteroids
GROSS APPR
Usually unilateral
1.5% bilateral
predominant microscopic pattern was tubular,
D/D- ENDO METRIOD CARCINOMA, CARCINOID TUMOR
DIFFERENTIATED BY IMMUNO HISTOCHEMISTRY- IN SERTOLI LEYDIG TUMOR-Epithelial membrane antigen (EMA) NEGATIVE USUALLY,INHIBIN POSITIVE AND CHROMOGRANIN NEGATIVE
EMA, inhibin, and chromogranin represent the most helpful triad of immunomarkers serving to exclude two common mimics of Sertoli cell tumors (endometrioid carcinoma [inhibin-; EMA+; chromogranin-] and carcinoid tumor [inhibin-; EMA+; chromogranin+]).
CD99 and calretinin are often expressed in these tumors, they are much less specific and not as helpful in the differential diagnosis.
The tumors typically occur in young females, sometimes children who typically present with sexual precocity, and occasional patients have Peutz-Jeghers syndrome.
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jayanta
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07.16.06 (2 years ago)
#3
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OOOOOPPPPSSSS,VIMOJ.
WHAT A GREAT REPLY    .
THANKX A LOT,FRIEND.
MY REGARDS.
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vimoj
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Re: OBSTETRICS-TUMOR
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07.16.06 (2 years ago)
#4
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| jayanta wrote: |
OVARIAN TUMOR WITH VIRILISATION IS:
1.GRANULOSA TUMOR.
2.SERTOLI-LEYDIG TUMOR.
3.TERATOMA.
4.GONADOBLASTOMA.
ANSWER GIVEN IS [2].
BUT WHAT IS THE SERTOLI-LEYDIG TUMOR,FRIEND?
I HAVE NO IDEA.
REGARDS. |
SERTOLI-LEYDIG CELL TUMOR/ANDROBLASTOMA- the main points
-very rare ovarian tumor
-grouped in the sex cord-stromal cell tumors
-known for producing various hormones and about 1/3 of cases may present with virilization.
- other patients, oligomenorrhea followed by amenorrhea may occur.
-Progressive masculinization and hirsuitism may also occur.
-However, 50% of these patients may have no endocrine symptomatology and instead have abdominal pain or swelling.
-Removal of the tumor results in a nomral menses in about 4 weeks.
- MEAN AGE -Mean 25 years
75%<30 years
- INCIDENCE- >0.5% of all ovarian tumors
INVESTIGATIONS
-Elevated levels of testosterone, androstenedione
-ELEVATED Urine 17-ketosteroids
GROSS APPR
Usually unilateral
1.5% bilateral
predominant microscopic pattern was tubular,
D/D- ENDO METRIOD CARCINOMA, CARCINOID TUMOR
DIFFERENTIATED BY IMMUNO HISTOCHEMISTRY- IN SERTOLI LEYDIG TUMOR-Epithelial membrane antigen (EMA) NEGATIVE USUALLY,INHIBIN POSITIVE AND CHROMOGRANIN NEGATIVE
EMA, inhibin, and chromogranin represent the most helpful triad of immunomarkers serving to exclude two common mimics of Sertoli cell tumors (endometrioid carcinoma [inhibin-; EMA+; chromogranin-] and carcinoid tumor [inhibin-; EMA+; chromogranin+]).
CD99 and calretinin are often expressed in these tumors, they are much less specific and not as helpful in the differential diagnosis.
The tumors typically occur in young females, sometimes children who typically present with sexual precocity, and occasional patients have Peutz-Jeghers syndrome.
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vimoj
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Re: OBSTETRICS-TUMOR
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07.16.06 (2 years ago)
#5
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| jayanta wrote: |
OVARIAN TUMOR WITH VIRILISATION IS:
1.GRANULOSA TUMOR.
2.SERTOLI-LEYDIG TUMOR.
3.TERATOMA.
4.GONADOBLASTOMA.
ANSWER GIVEN IS [2].
BUT WHAT IS THE SERTOLI-LEYDIG TUMOR,FRIEND?
I HAVE NO IDEA.
REGARDS. |
SERTOLI-LEYDIG CELL TUMOR/ANDROBLASTOMA- the main points
-very rare ovarian tumor
-grouped in the sex cord-stromal cell tumors
-known for producing various hormones and about 1/3 of cases may present with virilization.
- other patients, oligomenorrhea followed by amenorrhea may occur.
-Progressive masculinization and hirsuitism may also occur.
-However, 50% of these patients may have no endocrine symptomatology and instead have abdominal pain or swelling.
-Removal of the tumor results in a nomral menses in about 4 weeks.
- MEAN AGE -Mean 25 years
75%<30 years
- INCIDENCE- >0.5% of all ovarian tumors
INVESTIGATIONS
-Elevated levels of testosterone, androstenedione
-ELEVATED Urine 17-ketosteroids
GROSS APPR
Usually unilateral
1.5% bilateral
predominant microscopic pattern was tubular,
D/D- ENDO METRIOD CARCINOMA, CARCINOID TUMOR
DIFFERENTIATED BY IMMUNO HISTOCHEMISTRY- IN SERTOLI LEYDIG TUMOR-Epithelial membrane antigen (EMA) NEGATIVE USUALLY,INHIBIN POSITIVE AND CHROMOGRANIN NEGATIVE
EMA, inhibin, and chromogranin represent the most helpful triad of immunomarkers serving to exclude two common mimics of Sertoli cell tumors (endometrioid carcinoma [inhibin-; EMA+; chromogranin-] and carcinoid tumor [inhibin-; EMA+; chromogranin+]).
CD99 and calretinin are often expressed in these tumors, they are much less specific and not as helpful in the differential diagnosis.
The tumors typically occur in young females, sometimes children who typically present with sexual precocity, and occasional patients have Peutz-Jeghers syndrome.
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jayanta
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10.05.06 (2 years ago)
#6
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THANX VIMOJ.
REGRDS.
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Anooos
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10.30.06 (1 year ago)
#7
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other can secret androgen , althguhg less common, I expect hte Q is the most common one?!
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jayanta
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11.09.06 (1 year ago)
#8
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NO FRIEND, I HAVE POSTED AS THE QUESTION WAS IN THE BOOK!
THANKX.
REGARDS.
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Anooos
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11.09.06 (1 year ago)
#9
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IT IS SERTOLY, SURE.
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jayanta
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11.19.06 (1 year ago)
#10
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THANKX ALOT ANOOOS.
REGARDS.
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