Page 2 of 2: Nice doubts

SHASHANK_9 · Credits: 10382 My Scrapbook

its Metallothionein

reference harper 27/e page 596

phoenix_bhu · Credits: 2540 My Scrapbook

Metallothioneins (MTs) is a family of Cys-rich, low molecular weight (MW ranging from 3500 to 14000 Da) proteins. MTs have the capacity to bind both physiological (Zn, Cu, Se,...) and xenobiotic (Cd, Hg, Ag,...) heavy metals through the thiol group of its cysteine residues, which represents nearly the 30% of its amino acidic residues.

MTs plays role in protection against metal toxicity, regulation of physiological metals (Zn and Cu) and protection against oxidative stress. There are four main isoforms expressed in humans. In the human body, large quantities are synthesised primarily in the liver and kidneys. Their production is dependent on availability of the dietary minerals, as zinc, copper and selenium, and the amino acids histidine and cysteine.

phoenix_bhu · Credits: 2540 My Scrapbook

so most appropriate ans. is 'a' ,but wht is the ans in AAA?

SHASHANK_9 · Credits: 10382 My Scrapbook

ANS is A only Printing mistake in AAA.

phoenix_bhu · Credits: 2540 My Scrapbook

In Harper also it's given that they bind to Copper,zinc,cadmium, mercury,...........also they should not be binding to NH4+ (I think so b'coz it's not a metal ion) so appropriate ans is 'a'

SHASHANK_9 · Credits: 10382 My Scrapbook

Clonidine acts on presynaptic and postjunctional alpha-2-adrenoceptors. whats postjunctional ?

SHASHANK_9 · Credits: 10382 My Scrapbook

presynaptic blocker is

a. clonidine
b.yohimibine
c. methyldopa
d. phenoxybezamine

WHAT SHOULD BE ANSWER A/B?

answer given IN AAA is B.

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