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RxPG :: View topic - ATROPINE administered before general anaethesia  
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mightchillout


ATROPINE administered before general anaethesia
hi friendz..................


Why is ATROPINE administered before general anaethesia??

plz explain the mechanism....
icon_smile.gif icon_smile.gif

UNANSWERED: Topics division/frequency in final mbbs question papers?

s1986s
Aim MCh

[b]friend i am in second year and have studied mechanism of action of atropin so i'm explaining you best of my knowledge: -

1.atropin by having antinicotinic action reduses the secretions in body which produse byirritating property of classical anasthetic.hope you have studied in physiology about parasympathetic and sympathetic reseptors,
ATROPIN IS THE DRUG WHICH HAS GOT PROPERTY OF PARASYMPATHOLYTIC.

2.to prevent laryngospasm which occure due to increased respiratory secretions

3.to prevent cardiac arrythmias[induse by noradrenaline because halothane increase sensitvity of heart for atropin.


mightchillout


thnkz 1986.....dat was realli helpful........but can u plz explain this one.....

s1986s wrote:
to prevent cardiac arrythmias[induse by noradrenaline because halothane increase sensitvity of heart for atropin.



also..atropine hav wat effect on vomiting reflex? icon_smile.gif


krishna123
Aim CMC - Vellore

noradrenalin n atropine almost have same action b/c adrenalin is sympathomimetic n atropine is parasympatholytis drug. since both can be halpful in GA adrenalin is prefered to atropine while giving halothane because halothane increases sensitivity of heart to atropine causing increased arrythimias so better to use noradrenalin .
This is my explanation see for a better one


pearllysun
Aim Other

mightchillout wrote:
thnkz 1986.....dat was realli helpful........but can u plz explain this one.....

s1986s wrote:
to prevent cardiac arrythmias[induse by noradrenaline because halothane increase sensitvity of heart for atropin.



also..atropine hav wat effect on vomiting reflex? icon_smile.gif


first :

The effect of atropine premedication on the cardiovascular changes resulting from laryngoscopy and tracheal intubation in patients undergoing major surgery. Atropine administered does not affect the hypertensive response to laryngoscopy and tracheal intubation, but affects the tachycardia and increases the frequency of cardiac arrhythmia during intubation of the trachea.

second : atropine effects in

Central Nervous System

Dryness of the mouth with difficulty in swallowing or talking, thirst. These are due to
the reduction of salivary, bronchial and sweat secretions and are dose related.
Active and passive functions of the eustachian tube may be affected.
Tremor, fatigue, drowsiness, ataxia, mental confusion and/or excitement, dizziness, loss of taste, headache, nervousness, weakness, nausea, vomiting, insomnia, psychotic reactions, sedation and seizures. Anhidrosis also may occur and produce heat intolerance if the patient lives in a hot region . hyperthermia is also possible due to the inhibition of sweat secretions


Gastrointestinal
Constipation due to inhibition of parasympathetic control of the gastrointestinal tract . Paralytic ileus. Nausea, vomiting, retrosternal pain due to increased gastric reflux, bloated feeling.

hope your doubts are solved ! kindly write if you need more infos .

best wishes
pearllysun



mightchillout


icon_smile.gif icon_smile.gif


krishna123
Aim CMC - Vellore

u have solved most of my doubts but can we use atropine along wit halothane or not ?
or do they use any other drug ?


pearllysun
Aim Other

krishna123 wrote:
u have solved most of my doubts but can we use atropine along wit halothane or not ?
or do they use any other drug ?


im so happy that your doubts are almost cleared .

atropine with some drugs is used in anaesthesia such as halothane, suxamethonium and neostigmine


now you should know even the side effects using atropine , it could be this and even more :

* Dryness of the mouth with difficulty in swallowing and talking
* Thirst
* Reduced bronchial secretions
* Dilatation of the pupils (mydriasis) with loss of accommodation (cycloplegia)
* Photophobia
* Flushing and dryness of the skin
* Transient bradycardia followed by tachycardia with palpitations and arrhythmias
* Difficulty in micturition
* Reduction in the tone and mobility of the gastro-intestinal tract
* Constipation
* Vomiting
* Confusion
* Giddiness
* Staggering or impaired ability to walk


best wishes

pearllysun


krishna123
Aim CMC - Vellore

thank u pearllysun for clearing my doubts


mightchillout


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Essentials of Medical Pharmacology By KD Tripathi
Extensively revised and updated chapters to include recently introduced drugs, published information and therapeutic practices.
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