Page 1 of 1: Neurology,Medicine.Neuromyotonia autoantibodies

cingulate_gyrus2006 · Credits: 22790 My Scrapbook

Neuromyotonia is associatred with autoantibodies to.
a. Voltage -gated potassium channels.
b. Voltage gated calcium channels.
c. Neuromuscular junction.
d. Non of the above.

parin · Credits: 14470 My Scrapbook My Reading List 1 Books

The answer should be a) voltage-gated potassium channels..

Something from about neuromyotonia..

It is also known as Isaac's syndrome

It is d/t hyper-excitability of peripheral nerves..

C/F:

Muscle stiffness at rest that persists during sleep..
Delayed relaxation after voluntary effort(pseudomyotonia)..

distal muscles are affected most severely..

stiff gait
continuous muscle fiber contractions cause undulation of overlying skin- (myokymia or fasciculations)
excessive sweating d/t heat generated by continuous muscle fiber activity..
cramps..

Paraneoplastic neuromyotonia is a/w benign & malignant thymoma & Small cell Ca Lung

Lab findings:

EMG: fibrillations; fasciculations; doublet, triplet & multiplet single unit(myokymic) discharges, rarely high frequency neuromyotonic discharges..

Autoantibodies to voltage-gated potassium channels

Rx:

Plasma exchange

Phenytoin & Carbamazepine may also improve symptoms..

Harrison's..

		Sign In New User? Sign Up Sign in to access your control panel and messenger!
				TechZone \| SpiderNevi \| HowTo? \| Scrapbook!