Page 1 of 1: Q: pharmac- pharmacokinetics

dsha · Credits: 3173 My Scrapbook

hi,

here's something that i've been mulling over.
would appreciate ur views!

q. A drug achieves plasma level 16 mg/l shortly after oral adminstration of first dose. if t 1/2 and dosing interval are both 6h what is the plasma level shortly before giving 5th dose?

a. 15 mg/dl
b. 24 mg/dl
c. 28mg/dl
d. 30 mg/dl
e. 31 mg/dl

dr4jc · Credits: 4396 My Scrapbook

The ans is A. 15mg/dl....

The plasma conc at first is 16mg/dl.. after 6hrs (1st 1/2life) it is 8mg/dl and u give the next dose..so total is 24mg/dl..after 2nd t1/2 the conc is 12mg/dl and u give the next dose total now is 28mg/dl.. after 3rd t1/2 it is 14mg/dl..u give the next dose total is 30mg/dl.. after the 4th t 1/2 the dose will be 15mg/dl.

To make it easier to understand..

16mg/dl----> 8mg/dl+16mg/dl=24mg/dl----> 12mg/dl + 16mg/dl=28mg/dl---> 14mg/dl + 16mg/dl=30mg/dl---->15mg/dl(in 4 half lives)

So before the 5th dose it is 15mg/dl..

dsha · Credits: 3173 My Scrapbook

thanks!

its so simple once its explained.

shravani · Credits: 6477 My Scrapbook

sems to be simple after knowing the answer

shravani · Credits: 6477 My Scrapbook

_________________The polyposis syndrome which is not hereditary is:

A. Peutz-Jeghers

B. Gardner’s

c. Cronkhite-Canada

D. Turcot syndrome

E. Cowden’s disease

Whiterose · Credits: 1896 My Scrapbook My Reading List 8 Books

ITS C--CRONKHITE -Canada ..

shravani · Credits: 6477 My Scrapbook

hey that's right

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