Page 1 of 1: pharma- phase 2 blocker is

mehndi · Credits: 17550 My Scrapbook

phase 2 blocker is
1-D-TC
2-SCOLINE
3-COCAINE
4-VENCURONIUM

drsmita_s · Credits: 18609 My Scrapbook

phase 2 blocker is option 2) scoline or succinylcholine.

mehndi · Credits: 17550 My Scrapbook

answer is d- tc i suppose as scoline is dual blocker

drsmita_s · Credits: 18609 My Scrapbook

well, before coming to any conclusion read page no 311 of KDT.depolarizing agents produce dual mechanism neuromuscular blockade (under certain circumstances) which can b divided into two phases
phase 1 block and
phase 2 block ---> is slow in onset and results from desensitization of the receptor to ACh --> it therefore superficially resembles block produced by dTC.
so, the conclusion is dTC has nothing to do with phase 2 block,, it is just that phase 2 block resembles it's mechanism superficially.

u r right in saying that Scoline is a dual blocker, so, out of the options given only scoline can cause phase 2 block.

neo_the_one009 · Credits: 1601 My Scrapbook

neo_the_one009 · Credits: 1601 My Scrapbook

Okay frnds,
I got the answer....I hv searched thro many books and there are some contradictory opinions....
like from A.K.Paul-DRUGS AND EQUIPMENT IN ANAESTHETIC PRACTICE,4 th edition...In chapter 5 ,neuromuscular blocking agents...on page 59 there is classification on muscle relaxants:
A: Pharmacological level of action:
1.Curare like drugs-competitive PHASE 2
BLOCK
2.SUccinyl choline like drugs-non competitive
Phase 1 block

B: Physicological or cellular level of action:
1. Non depolarizing
2. Depolarizing.
Now on page 76,of A.K.Paul it is said that phase 1 block is also called DEPOLARIZING BLOCK,and the second form of block is called PHASE 2 BLOCK,desensitization block or dual block....WHICH RESEMBLES BLOCK PRODUCED BY NONDEPOLARIZING MUSCLE RELAXANTS with its associated characteristcs of tetanic fade,post tetanic facilitation and reversal with anti cholinesterase drugs..
So Here is some contradiction in the last paragraph and first classification...
So the dual block is the phase 2 block which is produced only by SUCCINYL CHOLINE,d-TC and Vecuronium produce Non depolarising block which is mimicked by succinylcholine in large doses...

SECOND AND MOST IMPORTANT REFERENCE IS FROM "MILLER",THE GOD FATHER BOOK IN Anaesthesia :-IT SAYS PHASE 2 BLOCK IS PRODUCED BY SUCCINYLCHOLINE.

so Here the controvercy ends...
I M SORRY Dr.Smita...But I hv to search a lot before saying sorry to U....
Good day!!!

drsmita_s · Credits: 18609 My Scrapbook

jayanta · Credits: 34262 My Scrapbook My Reading List 45 Books

GREAT DISCUSSION,SMITA AND ALL.
HAPPY INDEPENDENCE DAY.
REGARDS.

sankigowda · Credits: 194 My Scrapbook

scoline its a dual blocker

konveer · Credits: 640 My Scrapbook

Yep phase 2 block is caused by excessive successive doses of scoline.

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