Page 2 of 2: MCQ "2"

wasem · Credits: 8592 My Scrapbook

Question 7. The following statements are correct:

a. Bodybuilders can build up muscle indefinitely on a high-protein diet
True False

b. Smokers' bronchial epithelium is usually atrophic
True False

c. The lactating breast shows epithelial hyperplasia
True False

d. Oestrogen-producing ovarian cancer can cause endometrial hyperplasia
True False

e. The regenerative capacity of the liver is due to the fact that liver cells are labile
True False

a. Bodybuilders can build up muscle indefinitely on a high-protein diet (False)
b. Smokers' bronchial epithelium is usually atrophic (False)
c. The lactating breast shows epithelial hyperplasia (True)

Explanation: In pregnancy, there is a massive hormonal stimulus to the breast epithelium which leads to physiological hyperplasia and milk production. When hormone levels return to normal, lactation ceases and the epithelium returns to normal. Hyperplasia is a reversible process. Post-lactation, superfluous cells will be removed by apoptosis.
d. Oestrogen-producing ovarian cancer can cause endometrial hyperplasia (True)

Explanation: Some ovarian cancers can produce large amounts of oestrogen. The endometrium is a target epithelium of oestrogen and under the influence of excess, unopposed oestrogen will undergo hyperplasia. This may persist and become pathological and atypical, and ultimately lead to malignant (cancerous) change.
e. The regenerative capacity of the liver is due to the fact that liver cells are labile (False)

wasem · Credits: 8592 My Scrapbook

Question 8. The following statements are correct:

a. Atrophy involves necrosis of cells
True False

b. Metaplasia inevitably leads to neoplasia
True False

c. Growth factors may inhibit cell growth or division
True False

d. The myocardium of a hypertensive patient contains more myocardial cells than is normal
True False

e. The G1, S and G2 phases of the cell cycle together make up the interphase
True False

a. Atrophy involves necrosis of cells (False)
b. Metaplasia inevitably leads to neoplasia (False)
c. Growth factors may inhibit cell growth or division (True)

Explanation: Many growth factors are mitogenic - that is they stimulate cells to divide. Examples are epidermal growth factor (EGF), which causes liver and renal epithelial cells to divide, and platelet-derived growth factor (PDGF), which stimulates fibroblasts and smooth muscle cells. However, apparently paradoxically, some growth factors can actually inhibit cell growth; for example, transforming growth factor beta (TGF[bgr ]) and tumour necrosis factor (TNF). It is probably the balance between these types of growth factor which contributes to the stability of a cell population.
d. The myocardium of a hypertensive patient contains more myocardial cells than is normal (False)
e. The G1, S and G2 phases of the cell cycle together make up the interphase (True)

Explanation: Interphase is the period between mitoses in the cell cycle. It is the variability in the length of time of G1 which is mainly responsible for the difference in cell cycle time. The time taken for mitosis (1/2 to 1 hour) is fairly constant in most labile and stable cells.

wasem · Credits: 8592 My Scrapbook

Question 9. The following statements are correct:

a. Caseous necrosis is characteristically caused by ischaemia
True False

b. Carbon tetrachloride causes cell injury through free radicals
True False

c. Disaggregation of polyribosomes is an ultrastructural feature of reversible cell injury
True False

d. The brain is a common site for gangrenous necrosis
True False

e. Autolysis is characterised by a vital reaction to dead cells
True False

a. Caseous necrosis is characteristically caused by ischaemia (False)
b. Carbon tetrachloride causes cell injury through free radicals (True)

Explanation: Carbon tetrachloride poisoning is one of the prototypic examples of free radical-induced injury.
c. Disaggregation of polyribosomes is an ultrastructural feature of reversible cell injury (True)

Explanation: Although electron microscopy is rarely used to examine cell injury/death in day-to-day Pathology , it is important to have a working knowledge of the ultrastructural appearances of reversible and irreversible cell injury, if only for exam purposes.
d. The brain is a common site for gangrenous necrosis (False)
e. Autolysis is characterised by a vital reaction to dead cells (False)

rimpy · Credits: 1273 My Scrapbook

in b thalassemia,mc gene mutation is
cluster 1 inversion
intron 22
619 bp deletion
3.7 bp deletion

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