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docsa · Credits: 9033 My Scrapbook

While planning for a clinical trial for finding out the effect of a particular mouthwash on human subjects, which kind of study design will be able to give best results:
1. Randomized controlled trial with double blind planning.
2. Clinical trial with single blind plan and crossover
3. Randomized controlled trial with no blinding and cross-over.
4. Randomized controlled trial with double blind plan and cross-over

can anybdy explain all d choices 4 me thanx DEAR RXPG members
Hi, 2 u these Q. might appear very simple but 4 v bds pple these r bit difficult 2 ans. KINDLY help me by replin 2 my post THANX
Sincerely,
docsa
bds girl

SShah · Credits: 382 My Scrapbook

try

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docsa · Credits: 9033 My Scrapbook

thanx

younaw · Credits: 396 My Scrapbook

For me the option 4) is correct. I come from clincial trial background so it may be useful.

I will discuss in detail why is it so

see randomizaiton is must for any clinical trial, is n't it? bcoz without randomization there will bias. u can exclude option 2

after randomization is done there should either the study should be blinded or atleast cross over if not blinded, to avoid bias again, so that excludes option 4

now option one and four good ones, they compete but if u look at option it is best bcoz u have first randomization, then u double blinded the study, then u r also doing a cross over that means ( both group of patients getting Reference and Test products). Obviously option 4 will be better.

regards,
Yousuf Mohiuddin

shraddha · Credits: 19570 My Scrapbook

option 4 is the best but it is not economical + time consuming

younaw · Credits: 396 My Scrapbook

i agree its time consuming and costly.

kalika · Credits: 12497 My Scrapbook My Reading List 12 Books

but when we r talking abt best results.. thn we can b bit impractical too isntit

younaw · Credits: 396 My Scrapbook

yah, in terms of best i think u can a bit practical.

shuvo · Credits: 4585 My Scrapbook My Reading List 11 Books

Though not in the options, the best would be randomization with triple blinding....Here investigator, study subjects and even the data analysts dont know who is getting what.

jabby · Credits: 3703 My Scrapbook

i agree e younaw ans 4 is correct best option.as for ethical reason in crossover study no gr involved can remain untreated all subjects receive intervention but at diff time ,so i think it will be better to avoid bias that RCT should design with double blind and cross overstudy,beside expensive.

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