Page 1 of 1: foren 407 PCT necrosis

doctorgirl · Credits: 420 My Scrapbook

PCT necrosis is seen in .............poisoning
-phenol
-arsenic
-aconite
-lead

when my Forensic teacher taught me the nephrotoxic drugs he said

arsenic &mercury ,
cantharides and turpentine,
carbolic and oxalic acid

he did teach me No PCT DCT with it.........

if you are reading patho and came across the specific site of toxic action of these ........show some chivalry and help out the sweet little lady

please...........

doctorgirl78 · Credits: 5306 My Scrapbook

waiting for the knights to fight out this duel too.....................

where are you??

Sumit Seth · Credits: 77491 My Scrapbook My Reading List 262569 Books

Hi,
Poisons/drugs causing pct necrosis are

Memory Box--> P-PHENOL
C-Cresol,Canthradine,Corosive Sublimate(HgCl2)
T-Tetra Chloride(Carbon)

Ref: page 157 "Review of Forensic Medicine"-Dr.Sumit Seth

With Regards,
Sumit Seth[/img]

decembermist · Credits: 41021 My Scrapbook

arsenic : Glomerular nephritis

c/c lead poisoning : atherosclerotic nephritis & interstitial nephritis

phosphorous & copper : oliguria , hematuria , albuminuria & anuria

iodine : RED- BROWN URINE

DRATKINS · Credits: 8535 My Scrapbook

WHAT 'BOUT CADMIUM, DOES IT CAUSES PCT NECROSIS

professoranil · Credits: 165 My Scrapbook

Proximal Tubule (PT) consists of an initial convoluted portion (the proximal convoluted tubule or PCT) and a straight portion (the pars recta). The length of PT in humans is 14 mm (as compared to that of Distal convoluted tubule which is just 1 mm). PCTs are physically located in the cortex. PCTs as well as the pars recta, are qualitatively differentiated from the remainder of the nephron and collecting duct by their lumenal brush border, which can be recognized in routine H&E stains.

Proximal tubular toxins frequently affect both convoluted (PCT) and straight segments (the pars recta). The injury is caused via three main mechanisms. The mechanisms along with the toxins are as follows:

1. Direct perturbation of Cell or Subcellular Organelle Function

a. Aminoglycosides -> Gentamicin
b. Heavy Metals
i. Cadmium
ii. Mercury
iii. Lead

2. Xenobiotics that cause injury via Metabolic Activation with or without Organic Ion Transport. Here the chemical introduced in the body is not toxic as such, but liberates toxic byproducts, usually via microsomal MFOs (Mixed Function Oxidases). That is why the toxicity of these chemicals is reduced by agents which inhibit MFOs (e.g. piperonyl butoxide) and increased by agents which stimulate MFOs (e.g. polybrominated biphenyls)

a. Organohalides
i. Chloroform
b. Cephalosporins and other beta-lactam antibiotics
c. Mycotoxins
i. Ochratoxin A (incidentally Ochratoxin A is incriminated as the cause of Balkan nephropathy, which is an important syndrome in Eastern Europe)
ii. Fumosin-B
d. Halogenated Alkenes
i. Hexachloro-1,3-butadiene
ii. Tetrafluoroethylene
iii. Chlorotrifluoroethylene
iv. Trichloroethylene
v. Dichlorovinyl cysteine
e. Cisplatin

3. Xenobiotics perturbing cellular, interstitial, or Lumenal Substrate

a. Phosphate
b. Iron
c. Zinc
d. Ethylene glycol
e. Oxalate/oxalic acid
f. Amino acid toxicity -> Lysinoalanine (usually found in processed foods meant for human consumption) and Lysine. An amino acid, which is of interest here is D-serine. It induces necrosis which is restricted to pars recta (PCT is not affected by D-serine, but is mentioned just for completeness)

hariompriyom · Credits: 1660 My Scrapbook

ARSENIC

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