Page 1 of 1: pharmacology:volume of distribution for chloroquine is

draditithegreat · Credits: 1247960 My Scrapbook

volume of distribution for chloroquine is:
1.3-13L
13.1-130L
130.1-1300L
above -1300L??

nutsnitin · Credits: 15154 My Scrapbook

only thing i got..........:

Renal; 42 to 47% of chloroquine is excreted unchanged in the urine; 7 to 12% desethylchloroquine is excreted in urine 15.

Chloroquine is excreted very slowly and may persist in urine for months or years after medication is discontinued

Urine acidification increases renal excretion by 20 to 90%
HemodialysisHemodialysis increases the clearance of chloroquine; however, due to chloroquine's large volume of distribution, hemodialysis may not remove appreciable amounts in an overdose

draditithegreat · Credits: 1247960 My Scrapbook

this is what i got from net:

The volume of distribution (VD) is a pharmacological term used to quantify the distribution of a drug throughout the body after oral or intravenous dosing. It is defined as the volume in which the amount of drug would need to be uniformly distributed to produce the observed blood concentration. It is given by the equation:

The VD is not a real volume; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. solubility, charge, size, etc. The VD may also be used to determine how readily a drug will displace into the body tissue compartments relative to the blood:

<math>{V_{D}} = {V_{P}} + {V_{T}} \left(\frac{fu}{fu_{t}}\right)</math>
Where:

VP = plasma volume

VT = apparent tissue volume

fu = fraction unbound in plasma

fuT = fraction unbound in tissue

Some examples:

Warfarin VD = 8L Reflects a high degree of plasma protein binding

Theophylline VD = 30L Represents distribution in total body water

Chloroquine VD = 15000L Shows highly lipophilic molecules which sequester into total body fat

so d is the answer..

legolassildarin · Credits: 2318 My Scrapbook My Reading List 19 Books

chloroquine has the largest volume of distribution.for a man of 70 kg it is 13000L so the answer is D

super7 · Credits: 1996 My Scrapbook

it is 13,000L in a 70 kg man(Katzung)
10-1000L/Kg (anti-protozoal Katzung)

Because of the excess tissue binding we tend to give a large loading dose to saturate thses tissue binding sites & later give maintanence doses to achieve plasma conc.

ans.---d)

vivek_patel · Credits: 2551 My Scrapbook

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