Page 1 of 1: physiology -renal

kannan · Credits: 6918 My Scrapbook

y albumin is first to appear in urine in renal d/s?

DrJayKill · Credits: 2554 My Scrapbook

because its relatively smaller in size...

medico_mahesh · Credits: 893 My Scrapbook

is it the right answer mr drjaykill?i too donno.i have the same doubt basically.

trinity · Credits: 13371 My Scrapbook

I think 2 reasons:

1st is a jaykill said, i agree wid him. & second is the loss of anionic charge , d/t renal damage..glomerular rather

medico_mahesh · Credits: 893 My Scrapbook

thanks trinity

DRSUNDAY · Credits: 123 My Scrapbook

its because of its small size hence we talk about microalbuminuria, also with renal parenchyma destruction, the repelling property btw the -ve charge cell membrane and the -ve charged protein is LOST hence albumin smallest is first to appear.

vivek_patel · Credits: 2160 My Scrapbook

albumin is small sized ...thts the reason

spk · Credits: 178 My Scrapbook

basically,protein is not supposed to fillter out due to neg property of BM due to heparan sulphate,when in nephrotics conditions we see either glycosyalteion of BM making neg BM to positive so protein being neg in charge is attracte dto it and hence filltered out ===>indicates BM dis ,diabetes or other conditions!

chahar · Credits: 141 My Scrapbook

becuse of change in charges on glomeruli......... it become less negative.......

srini23dr · Credits: 357 My Scrapbook

bcoz of da size of da albumin and most importantly the negative charge of da albumin.....

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