Page 2 of 2: Blast crisis in CML is indicatedby all except

drlouis · Credits: 5374 My Scrapbook

is quantification of fever objectively( as high fever,low grade fever) is specific to blast crisis? probably any symptomatic change in an asymptomatic cml pts marks or should be thought of as the beginning of blast crisis- like onset of any fever (not responding to usual treatment),rapid enlargement of the spleen(hithereto reduced by the hydroxyurea or busuphan),apperance of new lymph nodes,appearance of bleeding gums or purpura,apperance of blasts -all depending on the rapidity and depth of neutropenia, thrombocytopenia , and anemia.so where are we now?

drkbravva · Credits: 24006 My Scrapbook My Reading List 1 Books

CML---->Acute phase, or blast crisis, is similar to acute leukemia, and survival is 3-6 months at this stage. Bone marrow and peripheral blood blasts of 30% or more are characteristic. Skin or tissue infiltration also defines blast crisis. Cytogenetic evidence of another Ph-positive clone (double) or clonal evolution (other cytogenetic abnormalities such as trisomy 8, 9, 19, or 21, isochromosome 17, or deletion of Y chromosome) is usually present.

A very large spleen is usually a harbinger of the transformation into an acute blast crisis form of the disease

suneet · Credits: 6820 My Scrapbook

FINAL ANS

viralbjmc2000 · Credits: 242 My Scrapbook

high grade fever

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