Page 1 of 2: medicine: Transfusion associated hepatitis?? B or C

AshB · Credits: 41913 My Scrapbook My Reading List 6 Books

Q. Which of the following hepatitis is associated with blood transfusion??
1. Hep A
2. Hep B
3. Hep C
4. Hep E

AshB · Credits: 41913 My Scrapbook My Reading List 6 Books

Answer given in all books i referred is Hepatitis C.
Now the confusion: Hariison 16th ed, pg 665, table 99-3 gives frequency of transmission of various agents per unit transfused.

Acco. to it Hep B transmission is about 25 times more common.
HBV= 1:63,000
HCV=1:1,600,000

* Even in the 15th edition HBV frequency was higher!

So what should be answer ???

AshB · Credits: 41913 My Scrapbook My Reading List 6 Books

Sorry i forgot to add a few words in d question,

The question reads..

Which of the following is MOST COMMONLY associated with transfusion??

candy · Credits: 15362 My Scrapbook

probably wat the ques means is the commonest mode of transmission for the mentioned viruses??
In that case hep b wil be sexual transmission rather than transfusion! Isnt it?

shraddha · Credits: 19600 My Scrapbook

even schwartz says
HCV was notorious for cause transfusion hepatits

nutsnitin · Credits: 15174 My Scrapbook

harry says.......As detailed below, most of the hepatitis transmitted by blood transfusion is not caused by HBV; moreover, in approximately two-thirds of patients with acute type B hepatitis, there is no history of an identifiable percutaneous exposure. We now recognize that many cases of type B hepatitis result from less obvious modes of nonpercutaneous or covert percutaneous transmission.

nutsnitin · Credits: 15174 My Scrapbook

also........ During the 1970s, the likelihood of acquiring hepatitis after transfusion of voluntarily donated, HBsAg-screened blood was approximately 10% per patient (up to 0.9% per unit transfused); 90 to 95% of these cases were classified, based on serologic exclusion of hepatitis A and B, as "non-A, non-B" hepatitis. For patients requiring transfusion of pooled products, such as clotting factor concentrates, the risk was even higher, up to 20 to 30%, while for those receiving such products as albumin and immune globulin, because of prior treatment of these materials by heating to 60°C or cold ethanol fractionation, there was no risk of hepatitis

ratnakar_potla · Credits: 5713 My Scrapbook My Reading List 2 Books

Here again I will go by my seniors advice:
"while attending indian exams never over think and while attending outside boards never pass on thinking its easy!!!!"
Now coming to this question as people already said it could have two meanings:
* which hepatitis commonly spreads through blood transfusion?
* each time you take a blood transfusion the chance for which hepatitis is more?
This question as I understand from its framing looks like from our desi boards (from the gyan given by senior takers) in that case
Ans: Hep C
otherwise taking in second sense ,following harri
Ans: Hep B

AshB · Credits: 41913 My Scrapbook My Reading List 6 Books

Thanks everybody for tryin 2 help me out.

Yes i agree if they want to know in which of the hep viruses the commonest mode of transmission is transfusion, then the answer maybe HCV. But what if the language clearly mentions risk of transmission of which hep virus is highest per unit transfused??? Then what??

I'd like to add..

Harri 14th edition/Pg 721
Risks of transfusion complication:
HBV= 1:200,000
HCV=1:103,000

Harri 15th edition/pg 736
HBV= 1:66,000
HCV=1:103,000

Harri 16th/pg 665
HBV= 1:63,000
HCV=1:1,600,000

These trends show that according to harri though earlier HCV was more common but now HCV has increased and gotten way past HBV.

The risk of transfusion associated HBV infection is 1 in 63000, 20 fold greater than for HCV. (harri 16th ed/pg667)

Some data suggest that HBV is more commonly transmitted by transfusion than HCV. (harri 15th ed/pg 738)... This statement is ambigous in itself and puts to doubt both versions of questions we have assumed??

Vagus · Credits: 671 My Scrapbook

hepatitis C is most commonly transmitted through blood transfusion !!!

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