Page 2 of 3: med---protein c deficiency?

Bruno · Credits: 44725 My Scrapbook My Reading List 50 Books

Few Facts About Forskalin

Derived from The herb Coleus forskohlii which is used by the Hindu traditional medicine to treat asthma, heart disease and more. The small mint-family herb is also found in Sri Lanka, Thailand, and Nepal.

In the 1970s, a chemically active ingredient called Forskolin was isolated from the herb . Now available in supplement form, this extract is commonly recommended for treating hypothyroidism, a condition in which the thyroid gland produces too little thyroid hormone. Forskolin is believed to stimulate the release of thyroid hormone, thus relieving such hypothyroidism symptoms as fatigue, depression, weight gain, and dry skin.

Specifically, forskolin is thought to increase thyroid function by activating an enzyme that raises levels of a key cell-regulating substance called cAMP (cyclic adenosine monophosphate).

Forskolin may be helpful to control the underlying cause of glaucoma. The sometimes successful use of forskolin to reduce intraocular pressure may be due to its unique ability to stimulate adenylate cyclase activity and increase cyclic adenosine monophosphate (cAMP) which regulates and activates critical enzymes required for the cellular energy required to move fluid out of the eye

To date, there have been two clinical studies examining the effectiveness of forskolin as a weight loss aid. Neither have yet been subject to peer-review or published in a medical journal. Additionally, according to the company that manufactures and administers the patented form of forskolin, two more clinical studies are being sponsored. Research update,

Only RxPG members can see links here! Register or Sign In!

June 2001.

* The diterpene forskolin was isolated for its pronounced biological activities.

-------------------

Forskolin is an important traditional Ayurvedic herb that has been a part of Indian medicine for centuries. Derived from roots of the plant Coleus forskohili, this herb is known to be a potent bronchodilator, able to relax the airways in the lungs and ease breathing. In this capacity it has been employed to treat imbalances resulting in asthma and other lung disorders. It has also been shown to relieve internal eye pressure, and may lead to new treatments for glaucoma.

The effects of Forskolin last for only a short period, and there are concerns that use may lead to possible cardiovascular complications. Forskolin would best be used under the supervision of a competent healthcare professional trained in its use.

Only RxPG members can see links here! Register or Sign In!

In the end I would like you to remember that This DRUG ACTIVATES Adenyl Cyclase

akanksha · Credits: 41247 My Scrapbook My Reading List 14 Books

well considering the GABA facilitatory(as well as GABA mimetic) action of barbiturates,can pheno be considered a relative of heparin(though a distant one!)?
i dunno yaar!i cant think anymore.my brain rebels.
dont laugh at my meagre knowledge.at least pheno doesnt inhibits GABA.
(hans lo,its ur day!)but do tell me the ans.

Bruno · Credits: 44725 My Scrapbook My Reading List 50 Books

Hi,

Phenobarbitone and other drugs of the GABA group act by opening/losing are ION CHANNELS (in this case Chloride Ion)

My question was about enzymes !!

What is the mechanism of action of Pralidoxime (P2AM - which you give in Organophosphorus poisoning !!)

Bruno

akanksha · Credits: 41247 My Scrapbook My Reading List 14 Books

BOLTI BAND!

Thanks Bruno for the enlightnment.Any other drugs in the list,apart frm PAM group?

doctorgirl78 · Credits: 5396 My Scrapbook

here are some drugs i dug up----------

pyridoxine activates dopa decarboxylase therefore abolishestherapeutic effect of L-dopa in parkinsonism

valproic acid activates enzyme involved in synthesis of GABA i.e. succinic semialdehyde dehydrogenase

leucovorin stimulates enzymes metabolising formic acid

glucocorticoids activates hepatic glycogen synthase

glucagon and adrenaline stimulates adenyla cyclase

methicillin stimulates penicillinase in some bacteria
and of course, PAM

the research's not complete though the list might be..........

Bruno · Credits: 44725 My Scrapbook My Reading List 50 Books

Excellent collection

akanksha · Credits: 41247 My Scrapbook My Reading List 14 Books

the hormone gene superfamily is divided into three subfamilies-

TYPE I includes the classical steroid receptors which include-

glucocorticoid receptors(including cortisol)
androgen receptors
mineralcorticoid receptors(including aldosterone)
progesterone receptors

TYPE II includes the thyroid related receptors('related' refers to retinoid receptors apart frm the thyroid receptors) and dihydroxy vitamin D3 receptors.

TYPE III includes the estrogen receptors & orphan receptors(orphan receptors r those for which no binding ligands hav been described,till date!)

out of these TYPE I & III hav cytoplasmic receptors.
while TYPE II bind directly to the nuclear receptors.

right bruno?

or wer u pointing at sumthin else? 8)

Bruno · Credits: 44725 My Scrapbook My Reading List 50 Books

Every one knows that Receptors for Thyroid hormone are in Nucleus

But of the steroid hormones

,Ganong Says that Estrogen Receptor is located in Nucleus

Thats about the hormones and now come to the other part of my second question.

What are the other drugs acting at Nucleus. 8)

akanksha · Credits: 41247 My Scrapbook My Reading List 14 Books

well the above information was collected frm harrison & sum journal paper.

raha,the drugs acting on nucleus,

what abt SPIRONOLACTONE--------i remeber it as the only diuretic acting thru nuclear receptors(compets with aldosterone);the rest of the diuretics mainly act by inhibiting carbonic anhydrase.

and what abt the antivirals,

acyclovir has an active metabolite which binds to nucleus.
idoxuridine also acts by binding to nucleus.

though these actions are actually competition with the BASES and prbly doesnt act thru a receptor pathway.

my random access memory cud give me only these.

shall refer but. 8)

doctorgirl78 · Credits: 5396 My Scrapbook

Arey baba ,if estrogen has a receptor in the nucleus then drugs which act on the receptor level ------clomiphene, tamoxifen bhi to consider karo………its just me or there are people out there who miss such obvious answers.
Mera kya hoga, Kaliya??
Waise this receptor thing troubled me a lot today. trip ,harry and ganong differ a lot.
But after the entire hullabaloo I went through, I am settling for estrogen and thyroid receptors in the nucleus and rest of the steroids may have fun in the cytoplasm.
What do you say Akku?

		Sign In New User? Sign Up Sign in to access your control panel and messenger!
				TechZone \| SpiderNevi \| HowTo? \| Scrapbook!