Page 3 of 3: med---protein c deficiency?

Bruno · Credits: 44755 My Scrapbook My Reading List 50 Books

Estrogen and Thyroid have receptors in Nucleus

All drugs which act via the DNA synthesis (including Folic Acid Metabolism) act through nucleus, though they may not have a nuclear receptor

spiderman · Credits: 502 My Scrapbook

rainbow_sly · Credits: 105 My Scrapbook

Well how about a 29 y/o with family history of heart attacks, and pt is male, 298 lbs, 6'7". No prevous problems. goes to ER cheast pains, pale, lack of O2, sweating, the ER runs test and concludes that he has deep thembrosis, and pulminary embolisim. The test revieled he had 2 tennis ball size blood clots pass through his heart and end up in his lungs, blocking air flow, he also had numerous quarter to golf ball size blood clots in lungs and throught out is legs. What do you think he has wrong. Any guesses he was diagnosed with Protein C defeciency, his 26 y/o sister then gets tested and the DR. concludes that she to has the protein C defeciency. Currently he is taking 7X the recomended dose of blood thinners and a filter was placed in blood stream to stop a blood clot from passing through his heart again

naseem · Credits: 1447 My Scrapbook

great stuff it stimulated the frontal lobe to great extent

nazia_k · Credits: 2890 My Scrapbook

its antithrombin iii deficiency
as mentioned by bruno key in this question is ApTT remains normal
An important point is that heparin (and also the low molecular weight heparins) do not thin the blood very effectively, thinners, if antithrombin III deficiency is present. This is because heparin's effect depends on the presence of antithrombin
so APTT will not be prolonged with usuall dose of heparin and higher doses will be required to gain the proper effect

THAMALIPXU · Credits: 100 My Scrapbook

I see many of your readers are interesting about medications and medicines, so now I going to touch that theme
information about medicines:
Clomiphene Citrate

Clomiphene citrate (brand name Clomid, Serophene) is used to induce ovulation. It revolutionized the field of infertility in the late 1950s.
Description

Clomiphene citrate is an orally administered medication. The initial dosage is 50 mg per day for five days, from day three to seven of the woman's cycle. The dose may be increased in subsequent cycles if the minimum dose does not result in ovulation.

Clomiphene citrate appears to act on the hypothalamus and is useful for women who do not ovulate because of hypothalamic or pituitary problems. Given early in the menstrual cycle (day three to seven), it suppresses the amount of naturally circulating estrogen. This "tricks" the pituitary into producing more follicular stimulating hormone (FSH) and luteinizing hormone (LH). These hormones then stimulate the ovary to ripen a follicle and release an egg. Of patients who are properly screened for use of this drug, about 70 percent will ovulate, and 40 percent of those will become pregnant. If a patient ovulates but does not become pregnant, the physician should check cervical factors. The anti-estrogenic effect of clomiphene citrate can create a "hostile" environment for conception.

We usually start with the lowest dosage to minimize adverse reactions. We then increase the dose in a subsequent cycle if ovulation does not occur. The patient should begin testing urine for an LH surge daily with an ovulation test kit, beginning on day 11 or 12 of the cycle. Call the office when an LH surge occurs.

In most cases, we will examine you with transvaginal ultrasound to see whether the follicles are ready for ovulation and check the size of the ovaries. If they are excessively enlarged, we will stop treatment until the ovaries are back to the pre-treatment size. If the follicles are ready to ovulate, we will proceed with your treatment, which may include scheduling an intrauterine insemination, or advising you when to have natural intercourse.

Another medications are

Butalbital and aspirin combination is a pain reliever and relaxant. It is used to treat tension headaches. Butalbital belongs to the group of medicines called barbiturates . Barbiturates act in the central nervous system (CNS) to produce their effects.

Alprazolam is used to treat anxiety and panic disorders attacks, Anxiety disorders are characterized by unrealistic worry and apprehension, causing symptoms of restlessness, aches, trembling, shortness of breath, smothering sensation, palpitations, sweating, cold clammy hands, lightheadedness, flushing, exaggerated startle responses, problems concentrating, and insomnia. Panic attacks occur either unexpectedly or in certain situations (i.e. driving), and can require higher dosages of alprazolam.
Norco is prescribed for moderate to moderately severe pain. This is available in tablet, capsule, and liquid form and is taken every 4-6 hours by mouth.
The Lortab is prescribed for moderate to moderately severe pain. Hydrocodone binds to the pain receptors in the brain so that the sensation of pain is reduced. care must be taken to follow the doctor's instructions when taking Lortab.
Flexeril should be used only for short periods (no more than 3 weeks) And may be taken with or without food.
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, 10/325 at

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, Vicoprofen,

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and Lortab,

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Thanks

theguyitay · Credits: 119 My Scrapbook

The correct reply to your query about Protein C deficiency is based upon the heterozygocity of the pt.

IF he truely were homozygous (got a recessive gene from both parents) then he would most likely have died before gestational completion or shortly after birth. This is a fatal situation!

Protein C Deficiency usually presents at puberty or late in life. AND usually is started by an ARTERIAL CLOT....causing a Pulmonary Embolism(i)

AND you also need to look closely into the possiblity that Protein S is possiblity which is not mentioned....but C modulates Factor V S modulates VIII and it is created earlier in the clottign process.

Sadness is that Protein C and S is very very difficult to assess or even predict since PT's usually present with DVT or PE without a prior history of any clotting problems and C and S both overlap. Best evidence that it is both is continued clottign problems after heparinization and NSAIDS admin with genetic checks.

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