Page 1 of 3: Local anesthesia

Actionking · Credits: 1838 My Scrapbook

What's the mechanism of local anesthesia ?

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draditithegreat · Credits: 1247960 My Scrapbook

1. 'A' fibres: myelinated somatic nerves,
2. 'B' fibres: myelinated preganglionic autonomic nerves, and
3. 'C' fibres: fine non-myelinated axons.

'A' fibres are further divided into alpha, beta, gamma and delta fibres, of decreasing diameter.

draditithegreat · Credits: 1247960 My Scrapbook

Na+ (Outside) 145 mMol/L
Na+ (Inside) 15 mMol/L
K+ (Outside) 5 mMol/L
K+ (Inside) 140 mMol/L

draditithegreat · Credits: 1247960 My Scrapbook

Local anaesthetic agents occupy Na+ channels and inhibit the rapid passage of Na+ ions and the propagation of the wave..

hey chand quoting from ur link only for a quick review of imp points.....hope u dont mind...

Actionking · Credits: 1838 My Scrapbook

Hiya dr Aditithe!!!

Thanks for your time and effort, It was a nice explanation.
i think you are an anesth.

Actionking · Credits: 1838 My Scrapbook

Hiya chand !!
Thanks for your help.

wondergirl · Credits: 13257 My Scrapbook

gud work aditi...

prasadkumaresan · Credits: 2294 My Scrapbook

local anaesthetics act by their membrane stabilising action.they block the sodium channels in open state

konveer · Credits: 640 My Scrapbook

i would like to add that they block the membrane from inside and they ought to be unionised to enter into the nerve fibre.

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