Page 3 of 3: Local anesthesia

impactedmolar · Credits: 449 My Scrapbook

LA PREVENT THE ENTRY OF SODIUM IONS INSIDE

THE NERVE FIBRES.INFLUX OF SODIUM WIL BE

PREVENTED. LONEST ACTING LA BUPIVACAINE,

SHORTEST ACTING CHLOR PROCAINE

jaldoc · Credits: 812 My Scrapbook

LA s predominant active species is cationic,enter the channel only from inner face of memb, and binds tightly to channel when it is inactive.

hence nerve fibre has to b active for la to act.

doc575 · Credits: 2511 My Scrapbook

hi all, i know this is the wrong place,bt sumhow there is a problm posting new topic in this forum,pl any1 clear this for me,is lee's handbook of anaesth same as lee's symposium,or diff.the small size buk is lee's symposium is only that 1 avlabl,or do we have a bigger lee's handbuk.pl reply.thanks

Gagan84 · Credits: 339 My Scrapbook

Voltage gated Na channels are responsible for propagation of Action potential. LAs block these channels ---> anaesthesia
as u know Nerve fibre types are TypeA(more diameter and myelinated and fastest conduction) TypeB (myelinated, intermediate velocity)Type C (least diameter, unmyelinated with least speed)
Order of blockade TypeC,B>Type Adelta >>> A alpha, beta, gamma
hence sensory fibres are blocked more than motor,
also peripheral most fibres in a nerve trunk are blocked preferentially, in the extremities the sensory fibres are most circumferential while vice versa proximally.

jayanta · Credits: 35983 My Scrapbook My Reading List 45 Books

BLOCKADGE OF Na+ CHANNEL IN EXCITABLE TISSUES.
REGARDS.

al-ain · Credits: 184 My Scrapbook

Which type nerve fibre will be blocked first ( C or B ) by LA?

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