Page 1 of 5: lepra bacilli best cultivated in

tulip · Credits: 21976 My Scrapbook

1. armadillos foot pad
2.mouse foot pad

nutsnitin · Credits: 15154 My Scrapbook

what harry says is.........M. leprae remains one of the few bacterial species that still has not been cultivated on artificial medium or tissue culture. The multiplication of M. leprae in mouse footpads (albeit limited, with a doubling time of ~2 weeks) has provided a means to evaluate antimicrobial agents, monitor clinical trials, and screen vaccines. M. leprae grows best in cooler tissues (the skin, peripheral nerves, anterior chamber of the eye, upper respiratory tract, and testes), sparing warmer areas of the skin (the axilla, groin, scalp, and midline of the back).

it has not talked even abt armadillos.....but dont know abt micro buks...

manpreet108 · Credits: 30682 My Scrapbook

i wd go with a...have read it in PSM ...and mcq books..
whats the ans given tulip?

shraddha · Credits: 19590 My Scrapbook

BEST cultivated
as i have always read is armadillo's foot pad
but practically it may mouse foot pad which may not be the best

tulip · Credits: 21976 My Scrapbook

manpreet and shradhha i agree with u ..cos i too believe tht armadillo is the BEST method (as yield is maximum)and foot pad of mice is most commonly used.

but mudit and another MCQ book gave answers as foot pad of mice.so can someone pls confirm this.thx

partha_aipg · Credits: 13088 My Scrapbook

the Dermatology faculty in IAMS said its the nine banded armadillo and even gave an explanation why it cannot be cultivated in any other type of armadillo(whichi have forgotten).

but tulip does not believe in iams

partha

lazybonezzz · Credits: 54675 My Scrapbook

actually partha is rite

decembermist · Credits: 41081 My Scrapbook

I've got a small doubt ! In the question its not specified which type of armadillo

oops sorrie for adding to the confusion

paddy241981 · Credits: 1628 My Scrapbook

i would go with foot pad of mouse because micro ananthanarayanan says mycobacterium leprae would cause similar symptoms as in humans but foot pad of mouse is used to culture the organism

micro ananthanarayanan 5 th edition page 343
" there have been many attempts to transmit leprosy to experimental animals. However, the real breakthrough was the discovery by sheprd [1960] that lepra bacilli could multiply in the foot pad of mouse kept at low temperratures 20 deg C. this observation has been confirmed and has become the standard procedure for experimental work with the bacillus."

harrison also says foot pad of mouse i would go with footpad of mouse

shraddha · Credits: 19590 My Scrapbook

hari says

Although it was the first bacterium to be etiologically associated with human disease, M. leprae remains one of the few bacterial species that still has not been cultivated on artificial medium or tissue culture. The multiplication of M. leprae in mouse footpads (albeit limited, with a doubling time of ~2 weeks) has provided a means to evaluate antimicrobial agents, monitor clinical trials, and screen vaccines. M. leprae grows best in cooler tissues (the skin, peripheral nerves, anterior chamber of the eye, upper respiratory tract, and testes), sparing warmer areas of the skin (the axilla, groin, scalp, and midline of the back

so it looks like MOUSE FOOT PAD

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