cyrus_Y_rus
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Sunday 18th of June 2006 11:00:44 AM (4 years ago)
#17
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i hav looked 4 this answer in many pages ,,,,,,,,n found that ,,,,,
1. there r actually many other drugs which r drug of choice for hypotensive anaeshesia ,,like ,,,,,,sodium nitroprusside , nitrogylcerine ,trimethaphan, ,,,,,,,,,,,,,,,so question shud be for best inhalational anesthetic for hypotensive anaesthesia ,,,
2. an extract 4m a site says '''''Hypotensive anesthesia reduces intraoperative blood loss. Studies have demonstrated a 2-4 fold reduction in intraoperative blood loss if mean arterial pressure (MAP) is reduced to 50 mmHg during surgery. If MAP is maintained at 60 mmHg rather than 50 mmHg, blood loss is about 40% greater. Thus the lower the pressure is reduced, the lower the blood loss. Blood loss during hypotensive anesthesia is related to MAP rather than cardiac output or central venous pressure. Postoperative wound drainage is not increased following hypotensive anesthesia. Consequently, most studies have shown a 50% reduction in in-hospital transfusion using hypotensive anesthesia.''''
3 . now ,,,,, this extract says the drug which can cause more fall in mean arterial pressure is more suitable n effective ......
4 . now among halothane n isoflurane ,,,,,,, halothane causes more hypotension ,,,,,,,, right ???
5 . now is this the only criteria to call it drug of choice ,,,,and is this what the examiner is trying to ask us ? ,,,,,,,,is ther something else ?
6 . isoflurane is definetly a superior drug to halothane ,,,,,,,,,,,,,n differences ,,,betwwen these drugs r ,,,,,,,, ,,,,,, isoflurane is less soluble in blood ,,,,hence has early induction n recovery ,,,,,,,, also ,,,,,, isoflurane is a safe drug with gud cardiac stability ,,,,,,where as halothane has toxic effect on liver + malignant hyperthermia n cant b used for long hours . ,,,,,,,,n ,,,,,, MAC of halothane is 0.75 where as isoflurane is 1.2 .,,,,,
7 . now .... if we can decide what actually is been asked ? ,then its simple to kno the answer .
8 ,BTW ,,,,,,,whats the answer given .,that can hint us ,what examiner wants to question .
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