Page 2 of 3: Atropine is useful in organophosphorus poisoning by inhibiti

dr4jc · Credits: 4396 My Scrapbook

You know that Atropine itself causes restlessness..

dr4jc · Credits: 4396 My Scrapbook

Dry as a bone
Hot as a hare
Mad as a hatter(CNS effects)
Red as a beet
Blind as a bat....

Thats an easy way to remember side effects of atropine

shabana · Credits: 11520 My Scrapbook

so in organophosphorus compuonds we will resort to use with atropine anticonvulsant as diazepam

is it right

arkascore · Credits: 673 My Scrapbook

Hi guys,
In organophosphorus poisoining we use mainly atropine and pralidoxime (Ach E activator). The other stuff that r used including diazepam are mainly part of supportive therapy.

Actually pralidoxime should have been the one and only drug because organophosphates are Ach E inactivators while pralidoxime is a Ach E reactivator. (so we are going to the root of the problem)

The reason that we use atropine is related to 2 insufficiencies of pralidoxime.....
1>It cannot really antagonise/stop the muscarinic actions of Ach (so we use atropine)
2>Pralidoxime doesn't really cross the blood brain barrier and so cant stop the central effects, and so we use atropine. Infact the reason that we use such high conc. of atropine at such frequent intervals (the exact dosage i have forgotten) in organophosphate poisoning is to achieve a sufficiently high central conc. of atropine.

In this context it may be useful to remember that almost all oximes act like pralidoxime but the only oxime that can cross the BBB is diacetyl mono oxime (DAM)

prasadkumaresan · Credits: 2294 My Scrapbook

answer is C

nishu9945 · Credits: 9569 My Scrapbook

well please open harrison chapter on poisoning and drug overdosage in the treatment of organophjosphorus poisoning it is clearly written that..
Neither Atropine nor Parlidoxime is particularly effective at reversing CNS effects;Seizure should be treated aggressively with BZD,s..
so no arguments now i guess..
it's further clearly mentioned that Atropine a mucuranic receptor antagonist should be administerd for muscurani effects.and if the quantity of poison ingested is high repeated toxicity may occur so we have to give a high dosage or continous infusion of atropine..

Atropine is useful in organophosphorus poisoning by inhibiting
a) Peripheral cholinergic actions
b) Sympathetic nerve fibres
c) Both central and peripheral actios....a
d) Central cholinergic actions
so the answer is
A)peripheral cholinergic actions

rajponn · Credits: 4434 My Scrapbook

The two naturally occurring compounds, atropine and hyoscine, are alkaloids found in solanaceous plants. The deadly nightshade (Atropa belladonna) contains mainly atropine, whereas the thorn apple (Datura stramonium) contains mainly hyoscine. These are tertiary ammonium compounds that are sufficiently lipid soluble to be readily absorbed from the gut or conjunctival sac and, importantly, to penetrate the blood-brain barrier. The quaternary derivative of atropine, atropine methonitrate, has peripheral actions very similar to those of atropine but, because of its exclusion from the brain, lacks central actions

answer is both central and peripheral actions

rajponn · Credits: 4434 My Scrapbook

reference rang and dale phamacology

zolt · Credits: 9181 My Scrapbook My Reading List 40 Books

Can anyone tell what is the contraindication of atropine in op poisoning?

GL · Credits: 656 My Scrapbook

i go with both Central & peri action!

		Sign In New User? Sign Up Sign in to access your control panel and messenger!
				TechZone \| SpiderNevi \| HowTo? \| Scrapbook!