Page 1 of 89: MAY AIIMS 08 Q & A with AUTHENTIC explanations

kavish · Credits: 36095 My Scrapbook

Frnds in continuation with my previous threads of aipg08,& nov aiims07,i will be posting Q & A with explanations.i got a lot of appreciation from u all,thnx a lot.may god gv all of u what u want.
i want othrs also to actively contribute QA,explanations & suggestions.

[size=24]i will try my best to gv correct ans but [size=24]to err is human & i m no exception.any difference of opinion is welcome[/size]

[color=violet][color=violet][color=brown]best of luck 4 results[/color][/color][/size][/color]

dramitmittal123 · Credits: 3193 My Scrapbook

thats great.....i have been waiting for u.....
1.bone marrow depression more in???quitiapine,resperidone???
2.portal system valve question?intrahepatic only....valveless?
3.positive nitrogen balance due to
4.bronchoscopy all seen except?
5.mott?
6.coefficient of variation?
7.macular degeneration in diabetes?

kavish · Credits: 36095 My Scrapbook

Q.marker for granulocytic sarcoma?
a)CD33
b)CD38
c)CD117
d)CD153

ans is c)CD117

ref:http://en.wikipedia.org/wiki/Granulocytic_sarcoma

A chloroma, or granulocytic sarcoma, or most appropriately, extramedullary myeloid tumor, is a solid tumor composed of immature malignant white blood cells called myeloblasts. A chloroma is an extramedullary manifestion of acute myeloid leukemia; in other words, it is a solid collection of leukemic cells occurring outside of the bone marrow.

Diagnosis
Definitive diagnosis of a chloroma usually requires a biopsy of the lesion in question. Historically, even with a tissue biopsy, pathologic misdiagnosis was an important problem, particularly in patients without a clear pre-existing diagnosis of acute myeloid leukemia to guide the pathologist. In one published series on chloroma, the authors stated that 47% of the patients were initially misdiagnosed, most often as having a malignant lymphoma.[7]

However, with advances in diagnostic techniques, the diagnosis of chloromas can be made more reliable. Traweek et al. described the use of a commercially available panel of monoclonal antibodies, against myeloperoxidase, CD68, CD43, and CD20, to accurately diagnose chloroma via immunohistochemistry and differentiate it from lymphoma.[8] Nowadays, immunohistochemical staining using monoclonal antibodies against [color=violet]CD34 and CD117 would be the mainstay of diagnosis[/color]. The increasingly refined use of flow cytometry has also facilitated more accurate diagnosis of these lesions.

u cn also read this link
http://www.encyclopedia.com/doc/1G1-80771885.html

kavish · Credits: 36095 My Scrapbook

Q.Malta fever is caused by?
a)
b)borrelia burgdorferi
c)brucella melitensis
d)pseudomonas

ans is c)brucella melitensis

Brucellosis, also called undulant fever, or Malta fever, in humans is a highly contagious zoonosis (infectious disease transmitted from animals to humans) caused by bacteria of the genus Brucella. Brucella spp. are small, gram-negative, non-motile, non-spore-forming rods. Brucella spp. are facultative intracellular parasites causing chronic disease, which usually persists for life. Brucellosis is a bacterial disease of both humans and animals recognized since the 19th century.

Brucellosis in humans is usually associated with the consumption of unpasteurized milk and soft cheeses made from the milk of infected animals, primarily goats, infected with Brucella melitensis and with occupational exposure of laboratory workers, veterinarians and slaughterhouse workers. Some vaccines used in livestock, most notably B. abortus strain 19 also cause disease in humans if accidentally injected. Brucellosis induces inconstant fevers, sweating, weakness, anaemia, headaches, depression and muscular and bodily pain.

manpan85 · Credits: 4146 My Scrapbook

YOU WERE BEING MISSED KAVISH... I AM A FAN OF YOUR POSTS... IF EVER YOU WROTE A BOOK I WILL BE THE FIRST CUSTOMER... NOW LETS WORK ON FINDING THE ANSWERS... WELCOME AGAIN...

manpan85 · Credits: 4146 My Scrapbook

YOU WERE BEING MISSED KAVISH... I AM A FAN OF YOUR POSTS... IF EVER YOU WROTE A BOOK I WILL BE THE FIRST CUSTOMER... NOW LETS WORK ON FINDING THE ANSWERS... WELCOME AGAIN...

dramitmittal123 · Credits: 3193 My Scrapbook

QUES ON CD99......
CD99

top

Also called MIC2, O13, T cell surface glycoprotein E2

Encoded by pseudoautosomal gene on short arms of X and Y

Part of Xg blood group system (website)

Functions: cell surface glycoprotein involved with (a) differentiation of primitive neuroectodermal cells (Exp Mol Med 2003;35:438), (b) apoptosis of T cells (FEBS Lett 2003;554:478), (c) T cell adhesion, (d) migration of leukocytes, (e) in Ewing’s/PNET, may promote growth and migration of tumor cells via downregulation of KCMF1 (potassium channel modulatory factor), a possible metastasis suppressor gene (Oncogene 2006;25:2795)

Associated with EWS-FLI1 fusion transcript, t(11;22)(q24;q12), causing FLI-1 protein overexpression

Interpretation: distinct membranous staining for Ewings/PNET; cytoplasmic for other tumors

Uses: relatively non-specific marker for Ewing’s sarcoma and T cell lymphoma, but does distinguish Ewing’s from neuroblastoma (Hum Path 1993;24:880); also distinguishes meningeal hemangiopericytoma (CD99+) from anaplastic meningiomas (CD99 weak/focal/negative, Hum Path 2004;35:1413); detect minimal residual disease by CD99+ flow cytometry in T-ALL (Leukemia 2004;18:703); anti-CD99 antibody may have therapeutic value (Eur J Cancer 2006;42:91)

ANS..ewing's

kavish · Credits: 36095 My Scrapbook

kavish · Credits: 36095 My Scrapbook

Q.drug used to perform stress ECHO?
a)thallium
b)dobutamine
c)dopamine
d)adenosine

ans is b)dobutamine

Pharmacologic Stress Test
Aka: Stress Imaging with Pharmacologic Provocation

Indications
Cardiac Screening in patients unable to Exercise 5 Mets
Intermediate pretest risk of CAD

Tests

Dobutamine Echocardiogram No Beta Blockers for 24 hours before test
Avoid if very large body habitus (poor echo window)
Optison contrast can be used to increase accuracy

Myocardial Perfusion Imaging with Adenosine
Avoid in severe COPD, Asthma, Carotid Stenosis
No nitrates on day of test
No methylxanthines (e.g. caffeine) for 24 hours prior

Myocardial Perfusion Imaging with Dipyridamole
Uses Dipyridamole (Persantine) instead of Adenosine
Determine Cardiac Risk pre-major non-cardiac surgery
May also help with prognosis after major surgery

Dobutamine Stress Echo Test
What is a dobutamine stress echo test?
The dobutamine stress echo test involves taking a medication called dobutamine while you are closely monitored. The medication stimulates your heart and makes it "think" it is exercising. The test is used to evaluate your heart and valve function when you are unable to exercise on a treadmill or stationary cycle.

The test is also used to:

Determine how well your heart tolerates activity;
Determine your likelihood of having coronary artery disease (blocked arteries); and
Evaluate the effectiveness of your cardiac treatment plan.

Contraindications
Concurrent Beta-Blocker use
Body habitus interferes with echocardiogram windows
Optison contrast can be used to increase accuracy

Advantages
Beta adrenergic agonist increases coronary flow 3x
More specific than Adenosine (but less sensitive)

jayakrishnav55 · Credits: 12205 My Scrapbook

heartiest welcom dr kavish. hopefully , by the grace of god, and best wushes of dr bruno and all of us, you shall be in top 20, preferably in top10. little luck is necessary. this time dams solutions will be written by dr smmreer kumar sethi and dr kavish. what a great co0mbination. pl bring out the book within 15 days with near perfect solutions. we promise to help you. pl reply and solve forst the puzzlers or thec twisters. god bless you my dearest freind.

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