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Quick Scroll Paediatrics ; Mock Test 64 treatment of infantile spasms 08.17.03 (5 years ago) #1
1) Treatment of choice in infantile spasm is

One answer only.

a) Phenobarbitone
b) Clonazepam
c) ACTH
d) Phenytoin



answers been marked wrong.
everybody knows that antiepileptics are not effective in west sydrome.
TOC is corticosteroids or ACTH.

or has some new research restored the efficacy of phenytoin here??? icon_surprised.gif
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Quick Scroll im with the doc! 08.17.03 (5 years ago) #2
I go with the doc(girl)! icon_smile.gif

ACTH is definitely the preferred treatment for infantile spasm.

as the theory goes like overproduction of CRH (in response to diff 'stress' an infant's brain is subjected to),which acts as a neurotransmitter and excites the neurons all arnd and cause the infantile spasms.

as the infant grows,the no. of CRH receptors decrease and spasms automatically gets 'cured'.

till this stg ACTH is used to decrease CRH secretion by FEEDBACK inhibition.

other drugs used are clonazepam.nitrazepam & vigabatrin.

not phenytoin anyway!

wat do ya say docs? 8)
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Quick Scroll forgot! 08.17.03 (5 years ago) #3
of course prednisolone is also used in conjunct with ACTH.

happy studying! icon_smile.gif
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Quick Scroll 08.17.03 (5 years ago) #4
doc girl is right.ACTH is the ans to the above ques

But there is some controversy whether ACTH or vigabatrin is the DOC of infantile spasm.?anyone having a definite ans to the above ques plzz reply
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Quick Scroll :-) 08.17.03 (5 years ago) #5
when in doubt stick to the established conventional treatments of choice,unless you find a standard textbook mentioning a differing opinion.
for the MCQs in paeds i stick to ghai so i'll go for pred & ACTH.
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Quick Scroll nelson! 08.17.03 (5 years ago) #6
nelson says "preferred treatment of infantile spasms is ACTH,combined
with prednisolone,if required"

i believe,this clears up any doubts remaining! icon_eek.gif
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Quick Scroll 01.07.06 (2 years ago) #7
the answer is ACTH.
its a simple question.
why such a simple question was posted????????
is there a trap in that???????????
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Quick Scroll 03.26.06 (2 years ago) #8
i go with akanksha.
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Quick Scroll 03.28.06 (2 years ago) #9
but do note Drug of choice in INFANTILE SPASM WITH Tuberous sclerosis is Vigabatrin..sorry I dont have a reference but will try get one
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Quick Scroll Re: <a href= 04.09.06 (2 years ago) #10
doctorgirl78 wrote:
1) Treatment of choice in infantile spasm is

One answer only.

a) Phenobarbitone
b) Clonazepam
c) ACTH
d) Phenytoin



answers been marked wrong.
everybody knows that antiepileptics are not effective in west sydrome.
TOC is corticosteroids or ACTH.

or has some new research restored the efficacy of phenytoin here??? icon_surprised.gif

Standard question = standard ans. = ACTH
No doubts or confusions regarding this one.
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