Page 1 of 1: gall stone

captainprasun · Credits: 1661 My Scrapbook

1) gall bladder stone formation is influenced by A/E.

a) clofibrate therapy
b) hyperalimentation
c) primary biliary cirrhosis
d) hypercholesterolemia

jian · Credits: 213 My Scrapbook

i guess hyperalimentation is the odd man out.
all other are possible factors promoting their formation.

guest · Credits: 78845 My Scrapbook My Reading List 262569 Books

Hyperalimentation causes gallstone formation. It is linked to both acalclous and calculous cholecystitis in infancy and also in adults. Primary biliary cirrhosis does not form stones. So the answer is c

vikram26 · Credits: 322 My Scrapbook

all of these are likely causes of increased all stone formation
but if one is to give an answer it will be c
because although cirrhosis leads to gs pbc

Primary biliary cirrhosis
PBC is a progressive cholestatic biliary disease that presents with fatigue and itching or asymptomatic elevation of the alkaline phosphatase. Jaundice develops with progressive destruction of bile ductules that eventually leads to liver cirrhosis and hepatic failure. This autoimmune illness has a familial predisposition, in which even unaffected family members may have immunologic abnormalities, especially an increased serum immunoglobulin M (IgM) and an association with human leucocyte antigen (HLA)-DR8.
While numerous autoantibodies have been identified, antimitochondrial antibodies (AMA) are present in 95% of patients. AMA is a family of antibodies; those directed against the inner mitochondrial membrane antigen M2 in the 2-oxo-acid dehydrogenase complex are most specific for PBC. Circulating immune complexes also have been identified but are unlikely to play a pathogenic role. Circulating T lymphocyte levels initially are within the reference range and decline as the disease progresses. The histologic appearance of the bile duct destruction resembles hepatic allograft rejection and graft-versus-host disease of the liver and appears to be mediated by cytotoxic T lymphocytes.

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