Page 1 of 1: lactulose

lazybonezzz · Credits: 54705 My Scrapbook

does it cause bacteria to use ammonia???

lazybonezzz · Credits: 54705 My Scrapbook

well heres a net link ---
The basic action of lactulose in hepatic encephalopathy is aimed at reducing nitrogenous intoxication by decreasing blood ammonia concentration. Lactulose is degraded in the large bowel by bacterial flora mainly to acetic and lactic acids thus reducing the intraluminal pH to below 5. This acidification of colonic contents results in the retention of ammonia as the ammonium ion. Ammonia, amines and various amides, and other basic nitrogenous substances are thus trapped reducing their absorption into the blood. Since the colonic contents are more acidic than the blood ammonia can be expected to migrate from the blood into the colon to form ammonium ion. Lowering of faecal pH is also thought to suppress urase producing organisms and to foster the growth of saccharolytic bacteria rather than E. coli, a more efficient ammonia producing bacterium. The diarrhoeal action of lactulose is synergistic in repelling the trapped ammonium ion from the colon
this means it does but ANY1 HAS A REF???.

pratik · Credits: 11374 My Scrapbook

lactulose is osmotic diuretic

used in hepatic encephalopathy.

a. decreases ph.
b decrease transit time of the material thus bacteria cannot act and produce ammonia.
c converts Nh3 to NH4+ thus not absorbed.

thus lactulose is first drug to be given in hepatic encephalopathy.

lazybonezzz · Credits: 54705 My Scrapbook

ref???

pratik · Credits: 11374 My Scrapbook

this is harrison

lazybonezzz · Credits: 54705 My Scrapbook

q says not produce but use ammonia i think that is true
check this---
The higher doses used for hepatic encephalopathy lower the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and improves mental function.
BUT I NEED A REF

lazybonezzz · Credits: 54705 My Scrapbook

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BRAVO · Credits: 45704 My Scrapbook

lazybonezzz · Credits: 54705 My Scrapbook

ya ya ya

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