Page 1 of 1: OBG - down syn

drprasu · Credits: 5755 My Scrapbook

a pregnant female,38 yrs old, is having a history of giving birth to baby with down's syndrome. how do you assess the risk
in present pregnancy

1) CVB
2) maternal AFP
3) maternal HCG
4) USG

drmeera · Credits: 616 My Scrapbook

CVB:: genetic
MSAFP: decreased
mat HCG: increased
USg:various anomalies of which nuchal thickness is normally measured and taken into account for the diagnosis!

so as she has the history cvb wud be better!

drprasu · Credits: 5755 My Scrapbook

actually question has specifically asked about assessing the risk which is done by serum tests.
CVB is used to make definitive diagnosis
and is done in those pts who are classified by
serum as having high risk in present pregnancy.

had the question asked how would you make diagnosis answer would have been CVB or
amniocentesis
but yes this is a high risk preg. as there is h/o
affected baby.
what is the percentage of recurrence of down syn. in subsequent pregnancy? is it 1%?

bhavu · Credits: 9491 My Scrapbook

pregnacies at risk see page 479 ghai5th edi
mother having previousabnormal offspring should be offered chorionic villus sampling at 10-12 weeksto determine gestation or aminocentesis around 16th week of pregnancy to determine the chromosomal status of the fetus.

in other women with low risk maternal serum afp, hcgand estriol assya(triple assyas)

drprasu · Credits: 5755 My Scrapbook

ya right, thanx

manpreet108 · Credits: 30702 My Scrapbook

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