Page 1 of 1: bleeding disorders

shraddha · Credits: 19600 My Scrapbook

20 yr.
pt. presents pre operative

aPTT :78/32
PT: 13/12
BT: 13min
Platelet : 350*100/microL

which one of the foll is true:
1. infusion of factor VIII
2. infusion of cryo ppt. will not be followed by improvement in coagulation
3.epistaxis is uncommon.
4.lack of platelet aggregation in response of ristocetin is a common feature of this disease

pl give explaination

guest · Credits: 79379 My Scrapbook My Reading List 262569 Books

I think this is a case of von willebrand disease and answer should be 4

ghaylank · Credits: 938 My Scrapbook

d is the answer

shraddha · Credits: 19600 My Scrapbook

i agree that von willebrand is the answer
but for treatment you give factor VIII
for a pre operative patient isn't that what should be the right answer

this is a from harria
""There are two therapeutic options. Factor VIII concentrates retain high-molecular-weight vWF multimers (Humate-P, Alfanate), are highly purified and heat-treated to destroy HIV, and are appropriate treatments for all the inherited forms of vWD. During surgery or after major trauma, patients should receive factor VIII concentrates twice daily for 2 or 3 days to assure optimal hemostasis. Minor bleeding episodes such as prolonged epistaxis or severe menorrhagia may respond to a single infusion. Recurrent menorrhagia, a major problem for women with severe vWD, can be treated effectively with oral contraceptive agents that suppress menses.
""

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