Page 1 of 1: physio : pulmonary arterial pressure

rsvv79 · Credits: 5424 My Scrapbook

rise in PAP is caused by

1. hypoxia
2. acidosis
3. alkalosis
4. all

q no 89 pg 60 Salgunan 05 edn.ans given 1.what abt 2 and 3??

gandalf · Credits: 8395 My Scrapbook

I think the answer shud be 1 n 2....

Harri says this :

Pulmonary Hypertension This is a common companion of many congenital cardiac lesions, and the status of the pulmonary vascular bed is often the principal determinant of the clinical manifestations, the course, and the feasibility of surgical repair. Increases in pulmonary arterial pressure result from elevation of pulmonary blood flow and/or resistance, the latter due sometimes to an increase in vascular tone but usually the result of obstructive, obliterative structural changes within the pulmonary vascular bed. Because pulmonary vascular obstructive disease can be the determining factor in assessing the advisability of operation, it is important to quantitate and compare pulmonary to systemic flows and resistances in patients with severe pulmonary hypertension. The causes of pulmonary vascular obstructive disease are unknown, although increased pulmonary blood flow, increased pulmonary arterial blood pressure, elevated pulmonary venous pressure, erythrocytosis, systemic hypoxemia, acidosis, and the bronchial circulation have been implicated.

decembermist · Credits: 41211 My Scrapbook

World Health Organization's Diagnostic Classification of Pulmonary Hypertension

Pulmonary arterial hypertension
Primary pulmonary hypertension
Sporadic disorder
Familial disorder
Related conditions
Collagen vascular disease
Congenital systemic-to-pulmonary shunt
Portal hypertension
Human immunodeficiency virus infection
Drugs and toxins
Anorectic agents (appetite suppressants)
Others
Persistent pulmonary hypertension of the newborn
Others

Pulmonary venous hypertension
Left-sided atrial or ventricular heart disease
Left-sided valvular heart disease
Extrinsic compression of central pulmonary veins
Fibrosing mediastinitis
Adenopathy and/or tumors
Pulmonary veno-occlusive disease
Others

Pulmonary hypertension associated with disorders of the respiratory system and/or hypoxemia
Chronic obstructive pulmonary disease
Interstitial lung disease
Sleep-disordered breathing
Alveolar hypoventilation disorders
Chronic exposure to high altitudes
Neonatal lung disease
Alveolar-capillary dysplasia
Others

Pulmonary hypertension resulting from chronic thrombotic and/or embolic disease
Thromboembolic obstruction of proximal pulmonary arteries
Obstruction of distal pulmonary arteries
Pulmonary embolism (thrombus, tumor, ova and/or parasites, foreign material)
In-situ thrombosis
Sickle cell disease

Pulmonary hypertension resulting from disorders directly affecting the pulmonary vasculature
*Inflammatory conditions
Schistosomiasis
Sarcoidosis
*Others
*Pulmonary capillary hemangiomatosis

decembermist · Credits: 41211 My Scrapbook

decembermist · Credits: 41211 My Scrapbook

Risk Factors for Primary Pulmonary Hypertension

Drugs and toxins
Definite causal relationship
Aminorex
Fenfluramine
Dexfenfluramine
Toxic rapeseed oil
Very likely causal relationship
Amphetamines
L-Tryptophan
Possible causal relationship
Meta-amphetamines
Cocaine
Chemotherapeutic agents
Unlikely causal relationship
Antidepressants
Oral contraceptives
Estrogen therapy
Cigarette smoking

Demographic factors and medical conditions
Definite causal relationship
Gender
Possible causal relationship
Pregnancy
Systemic hypertension
Unlikely causal relationship
Obesity

Diseases
Definite causal relationship
Human immunodeficiency virus infection
Very likely causal relationship
Portal hypertension and/or liver disease
Collagen vascular diseases
Congenital systemic-to-pulmonary cardiac shunts
Possible causal relationship
Thyroid disorders

gandalf · Credits: 8395 My Scrapbook

!!!!!!!!!!!!!!!!!!!!!!!!!

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