Page 1 of 1: *******MICROBIOLOGY-PLEASE HELP ME

dhiman · Credits: 1893 My Scrapbook

DEAR FRIENDS,I AM UNDER A LOT OF CONFUSION FOR THE FOLOWING FEW QUESTIONS:
I NEED YOUR VALUABLE ADVICES REGARDING EXPLANATION & CORRECT ANSWER OF THIS Microbiology QUESTIONS.
AIIMS NOV2003
----------------------
1.EARLY DIGNOSIS OF ACUTE HEPATITIS B INFECTION IS DONE BY:
AIIMS NOV2001
------------------------
2.RECENT HEPATIC INFECTION BY HEPA. B VIRUS IS BEST DIAGNOSED BY:
3.ACUTE HEPATTIS B CAN BE AT EARLIEST DIAGNOSED BY:
OPTIONS IN AL 3 QUESTIONS AE:
A.HbSAg.
B.ANTI HbSAg Ab.
C.IgG ANTI HbCAgAb.
D.IgM ANTI HbCAgAb.
FOR THE ANSWERS OF ALL THESE QUESTIONS,THEE ARE 2 SCHOOLS OF OPINIONS I AM GETTING FROM DIFFERENT BOOKS:
1.ONE SCHOOL IS SAYING QUESTIONS ARE ALL ABOUT SEARCHING THE EARLEST VIROLOGICAL MARKER.THEY BELIEVE ANSWER IS OPTION [A].
2.THE SECOND THOUGHT OF SCHOOL TELLS IT IS AL ABOUT CONFIRMATION OF DIAGNOSIS OF ACUTE HEPATITIS B.
SO,THEY ARE TELLING IT MUST BE OPTION[D].
I AM IN GREAT DILEMA.
PLEAE HELP ME. THANK YOU.

ratnakar_potla · Credits: 5703 My Scrapbook My Reading List 2 Books

Early implies earliest and I was taught in school A and i ill go for HbS Ag

dhiman · Credits: 1893 My Scrapbook

i know it's [a],but for confirmation is not it AntiHbCIgM?
reply please.

shraddha · Credits: 19580 My Scrapbook

i agree with diman
the recent & active infection is best diagnose by IgM Hbc ab
becoz HbsAg may be present post vaccination

ratnakar_potla · Credits: 5703 My Scrapbook My Reading List 2 Books

Oh ya thanx for that its tue that Hbs ag is found even post vaccination. So it cant be the answer

vineetgsvm · Credits: 122703 My Scrapbook

YEAH D IS THE CORRECT ANSWER FOR REASONS SITED ABOVE......
POST VACCINATION ANTI HBs WUD BE POSITIVE NOT ANTI HBc..

jayanta · Credits: 34977 My Scrapbook My Reading List 45 Books

GOOD QUESTION DHIMAN.
WHERE DO YOU RESIDE

drprashantpurohit · Credits: 161 My Scrapbook

There is a minute, but clear difference between the "Earliest diagnosis" and "Evidence of recent infection". To diagnose the hepatitis B at the earliest, the best thing is to go for HBsAg, while HBcIgM appears later than it, but if present, is an important marker of recent infection, while its absence and presence of HbcIgG denotes a remote infection. In contrast, the patient may be HBsAg +ve for years together, even after the convalescence from the acute disease, but this is the first marker to appear on the first contact with the infection. I hope, it would be helpful.
-Dr. Prashant Purohit

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