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kalikaSend an Instant Message to kalika  




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Quick Scroll maximum the intracellular conc.. 12.07.05 (2 years ago) #1
:idea:_____drug attain maximum conc. intracellulary , after absorption :
1. acidic drugs
2. basic drugs
3. same for both
4. can't be pridicted
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Quick Scroll 01.24.06 (2 years ago) #2
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Quick Scroll 01.24.06 (2 years ago) #3
Normally the intracellular pH (6.9 - 7.2) is slightly less than the pH of plasma/interstitial fluid (7.4). If only this principle is taken into consideration then the basic drugs which are less ionized at higher ph would easily diffuse through membrane but since the intracellular pH is low, the drugs would ionize there and therefore get trapped. That means basic drugs should reach higher intracellular concentration......
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Quick Scroll 01.26.06 (2 years ago) #4
icon_smile.gif thanx sonia.. ans givn was acidic so i was confused.. cos logic says BASIC shud b the ans ..
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Quick Scroll Shouldn't they mention the site of absorption? 01.28.06 (2 years ago) #5
But then wouldn't be the answer different if the site of absorption of the drug is stomach? Stomach with its low pH causes ionisation of basic drugs and they may not be absorbed intracellularly. Am I right? icon_question.gif The scenario is different after the level of duodenum.
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Quick Scroll Re: Shouldn't they mention the site of absorption? 01.29.06 (2 years ago) #6
doctor82 wrote:
But then wouldn't be the answer different if the site of absorption of the drug is stomach? Stomach with its low pH causes ionisation of basic drugs and they may not be absorbed intracellularly. Am I right? icon_question.gif The scenario is different after the level of duodenum.


yes..wht u r saying is absolutely right ..but i m now confused again..
can somebody pls xplain wht q is asking
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Quick Scroll 01.29.06 (2 years ago) #7
Consider the fact of NSAIDS which are trapped in gastric cells . NSAIDS are acidic drugs . Hence acidic drugs should be the ans
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Quick Scroll 01.29.06 (2 years ago) #8
In my reply I assumed that the drug is already in plasma because the question mentions "after absorption". Otherwise, the answer can not be predicted if the problem encompasses GI tract absorption!!
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