Page 1 of 2: Oncology - Most imp prognositc factor in operable

decembermist · Credits: 41081 My Scrapbook

breast carcinoma

a) tumour size
b) axillary node status
c) labelling index
d) PS
e) menopausal status

ans not given

nutsnitin · Credits: 15154 My Scrapbook

dont know what does operable mean here..........but as far as i have read,most imp prognostic factor for breast cancer( either male or female) is axilary lymph nodes..

shraddha · Credits: 19590 My Scrapbook

whats'PS
hari
The most important prognostic variables are provided by tumor staging. The size of the tumor and the status of the axillary lymph nodes provide reasonably accurate information on the likelihood of tumor relapse.

??

decembermist · Credits: 41081 My Scrapbook

Donno abt PS - its given like tht only

draditithegreat · Credits: 1247960 My Scrapbook

actually its tumour / the good tissue(their proportion)
like in two diff patient ,has 5cm each tumour size but in one it is affectiing 1/4th of it and other 3/4th of it...
so the strategy regarding management changes...
and so the prognosis.....

but we cant ignore the the lymph nd status as such for prognois....

but when the prognosis depending on the operability is asked we have to go for tumour/good tissue...

{now if someone gonna ask me ref} i ll be in a fix bcaz i have read this loooooong back...

flowerchildn · Credits: 7753 My Scrapbook

its axillary ln status sure

ora · Credits: 1227 My Scrapbook

B>>>>A

shraddha · Credits: 19590 My Scrapbook

it has to be tumour size more than lymph node

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Survival in breast cancer depends on multiple social, biologic, and independent patient factors.

Accessibility to medical care, compliance with screening, level of education, and socioeconomic status all can impact the stage at which breast cancer first is diagnosed, which therefore influences survival.

Race has been associated with mortality from breast cancer in American women. The National Cancer Institute reported a 57% survival for black women versus 71% for white women.

Genetic predisposition also can influence outcome. Once diagnosis has been achieved, tumor size, receptor status, and axillary node involvement can affect prognosis.

A 20-year follow-up study from the BCDDP found overall 20-year survival rates regardless of age, stage, or treatment to be greater than 78%. For women aged 40-49 years, survival rate was 80% without accounting for stage and treatment. Older women (60-69 y) had a lower overall survival rate of 76%.

Tumor size clearly is associated with higher mortality. Lesions greater than 5.0 cm were associated with a 50-60% 20-year survival rate compared to those less than 1 cm, which had a 93-[snip]% 20-year survival rate. The BCDDP also found, predictably, that nodal involvement also negatively influenced survival rates.

Choice of treatment modality also has significance with respect to survival. As discussed above, no statistically significant difference in survival was noted for patients with stage I and II breast cancers treated with breast conservation versus mastectomy.

The standards of preoperative, operative, and adjuvant treatment require continuous reassessment in randomized controlled clinical trials.

ora · Credits: 1227 My Scrapbook

IT WAS A VERY NICE LINK.

BUT TUMOR SIZE AND LYMPH NODES STATUS IS NOT COMPAIRED
STATISTICALLY.

HAR MENTION STAGING IN THE MOST IMP INDICATOR SO BOTH ARE IMP

METS>LN>TUMOR SIZE {M>N>T}

Cad Saude Publica. 2004 Sep-Oct;20(5):1232-9. Epub 2004 Oct 13. Related Articles, Links

[Tumor characteristics and five-year survival in breast cancer patients at the National Cancer Institute, Rio de Janeiro, Brazil]

Mendonca GA, Silva AM, Caula WM.

Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

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Numerous factors have been studied to establish more secure prognostic criteria in breast cancer patients. This study estimates five-year survival rates and principal prognostic factors related to tumor characteristics in women with invasive breast cancer and submitted to surgery at the National Cancer Institute, Rio de Janeiro, Brazil, from May 1995 to July 1996. Study variables were: lymph node status, tumor size, aggressiveness grade, and presence of estrogen and progesterone receptors. Survival functions were calculated according to the Kaplan-Meyer method. The Cox proportional hazards model was used to evaluate prognostic factors. Five-year survival was 75% for all women and 64% for those with node involvement. Multivariate analyses identified node involvement as the strongest predictor of outcome; a positive estrogen receptor test was associated with a better prognosis. These findings highlight the need for studies to assess new variables to be added to known factors in order to better orient therapy for breast cancer.

I DONT HAV SURGERY BOOKS

BUT I WILL STICK TO MY ANS

drsweta06 · Credits: 5916 My Scrapbook

its axillary node status

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